Effect of hot water extract of Chlorella vulgaris on cytokine expression patterns in mice with murine acquired immunodeficiency syndrome after infection with Listeria monocytogenes
Effect of hot water extract of Chlorella vulgaris on cytokine expression patterns in mice with murine acquired immunodeficiency syndrome after infection with Listeria monocytogenes
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DOI：
10.1016/s0162-3109(96)00150-6
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发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Yoshikai, Y
中科院分区：
文献类型：
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作者：
Hasegawa, T;Kimura, Y;Yoshikai, Y
我们此前曾报道，口服普通小球藻热水提取物(CVE)可增强正常小鼠和由小鼠白血病病毒(MuLV)LP-BM5引起的小鼠获得性免疫缺陷综合征(MAID)小鼠对李斯特氏菌的特异性细胞免疫应答。为了阐明CVE增强细胞免疫的机制，我们检测了感染单增李斯特氏菌后口服CVE的正常和未成年小鼠细胞因子mRNA的表达模式。灌胃给药后，腹膜贴壁细胞IL-1α、IL-12、GM-CSF、MIP和TNFα基因的表达水平显著升高。
We have previously reported that oral administration of hot water extract of Chlorella vulgaris (CVE) enhances resistance to Listeria monocytogenes through augmentation of Listeria-specific cell-mediated immunity in normal mice and mice with murine acquired immunodeficiency syndrome (MAIDS) caused by murine leukemia virus (MuLV) LP-BM5. To elucidate the mechanisms whereby CVE augments the cell-mediated immunity, we examined the expression patterns of mRNA for cytokines in normal and MAIDS mice given CVE orally after L. monocytogenes infection. The expression levels of IL-1 alpha, IL-12, GM-CSF, MIP and TNF alpha genes were significantly augmented in the peritoneal adherent cells by oral.