Set shifting and reversal learning in patients with bipolar disorder or schizophrenia
Set shifting and reversal learning in patients with bipolar disorder or schizophrenia
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DOI：
10.1017/s0033291708004935
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发表时间：
2009-08-01
影响因子：
6.9
通讯作者：
McIntosh, A. M.
中科院分区：
文献类型：
--
作者：
McKirdy, J.;Sussmann, J. E. D.;McIntosh, A. M.
背景。双相情感障碍和精神分裂症都与超维度集合移位（EDS）缺陷有关。逆向学习（RL）缺陷也出现在精神分裂症中，但没有出现在双相情感障碍中。本研究试图通过直接比较患有每种疾病的临床稳定患者来评估这些发现的特异性。方法。维度内/维度外 (IDED) 设定转换任务是剑桥神经心理学自动测试组 (CANTAB) 的一部分，对 30 名精神分裂症患者、47 名双相情感障碍患者和 44 名未受影响的对照组进行了测试。比较各组之间的 EDS 和 RL 误差，并与当前和过去的精神症状和药物治疗的测量结果相关。两组精神分裂症或双相情感障碍患者的 EDS 和 RL 错误均高于对照组。即使分析仅限于情绪正常的患者，这两种方法也无法区分这两种疾病。没有发现与处方药物有关系。结论。双相情感障碍或精神分裂症患者在 EDS 和 RL 方面表现出常见的缺陷。这些缺陷似乎与当前的症状无关，并且与涉及腹侧前额叶皮层的网络中断一致。
Background. Bipolar disorder and schizophrenia have both been associated with deficits in extra-dimensional set shifting (EDS). Deficits in reversal learning (RL) have also been shown in schizophrenia but not in bipolar disorder. This study sought to assess the specificity of these findings in a direct comparison of clinically stable patients with each disorder.Method. The intra-dimensional/extra-dimensional (IDED) set-shifting task, part of the Cambridge Neuropsychological Test Automated Battery (CANTAB), was administered to 30 patients with schizophrenia, 47 with bipolar disorder and a group of 44 unaffected controls. EDS and RL errors were compared between the groups and related to measures of current and past psychiatric symptoms and medication.Results. Both groups of patients with schizophrenia or bipolar disorder made more EDS and RL errors than controls. Neither measure separated the two disorders, even when the analysis was restricted to euthymic patients. No relationship was found with prescribed medication.Conclusions. Patients with bipolar disorder or schizophrenia show common deficits in EDS and RL. These deficits do not seem to be attributable to current symptoms and are consistent with disrupted networks involving the ventral prefrontal cortex.