Changes in BMI and weight before and after the development of type 2 diabetes
Changes in BMI and weight before and after the development of type 2 diabetes
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DOI：
10.2337/diacare.24.11.1917
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发表时间：
2001-11-01
期刊：
影响因子：
16.2
通讯作者：
Hanson, RL
中科院分区：
文献类型：
--
作者：
Looker, HC;Knowler, WC;Hanson, RL
目的-检查发生在糖尿病诊断前后的体重变化，以及这些变化与治疗和微血管并发症的相关性。研究设计和方法-我们对1965年至2000年期间在亚利桑那州中部吉拉河社区的居民进行的一系列检查进行了分析。数据取自816名个体的4,226次检查，这些个体在纵向研究的过程中发展为糖尿病，并且在诊断前4年内接受了非糖尿病检查。我们测量了两次检查之间BMI的变化。结果-在诊断糖尿病之前，体重稳步增加：平均BMI每年在0.43和0.71 kg/m2之间攀升。诊断后，体重增加下降，体重减轻，BMI的平均变化率范围为-0.61和+0.22 kg/m2/年。当考虑目前的治疗时，与未服用降糖药物的个体相比，服用胰岛素的个体的体重稳定性更高。在分析的大多数时间间隔内，药物是体重变化的统计学显著因素。有没有统计学显着关联与视网膜病变或nephropathy.CONCLUSIONS -糖尿病的发展之前，有一个渐进的体重上升，并在诊断后，有体重减轻的趋势，减肥干预糖尿病患者将需要考虑到这种趋势，如果他们要成功地修改，病程。
OBJECTIVE - To examine weight changes occurring before and after the diagnosis of diabetes and the association Of these changes with treatment and microvascular complications.RESEARCH DESIGN AND METHODS - We undertook an analysis of serial examinations conducted between 1965 and 2000 in residents of the Gila River Community in Central Arizona. Data were taken from 4,226 examinations of 816 individuals in whom diabetes developed over the course of a longitudinal study and who had undergone a nondiabetic examination within 4 years preceding diagnosis, We measured changes in BMI between examinations.RESULTS - Before diagnosis Of diabetes, there were steady gains in weight: mean BMI climbed between 0.43 and 0.71 kg/m(2) per year. After diagnosis, the weight gain declined, and weight loss was generally seen the mean rate of change of BMI ranged between -0.61 and +0.22 kg/m(2) per year. When current treatment was considered, there was greater weight stability in individuals taking insulin compared with those not taking hypoglycemic medication. Medication was a statistically significant factor for change in weight for Most of the time intervals analyzed. There was no statistically significant association with retinopathy or nephropathy.CONCLUSIONS - Before development of diabetes, there was a progressive rise in weight , and after diagnosis, there was a tendency toward weight loss, Weight-loss interventions in individuals with diabetes will need to account for this tendency if they are to successfully modify, the course of the disease.