Lipase-catalyzed preparation of peroxy acids and their use for epoxidation
Lipase-catalyzed preparation of peroxy acids and their use for epoxidation
复制标题
DOI：
10.1016/s1381-1169(96)00264-6
复制
发表时间：
1997-03-14
影响因子：
--
通讯作者：
Warwel, S
中科院分区：
文献类型：
--
作者：
Klaas, MRG;Warwel, S
利用脂肪酶催化的羧酸和羧酸酯与过氧化氢的反应，在室温下且无需无机酸的情况下生成各种过氧酸。尽管Novozym 435（R）将仅能够催化游离的无支链羧酸转化为过氧酸，但α-甲基取代的羧酸乙酯可以通过使用相同的酶进行过水解而转化为过氧酸。这些过氧酸被用于不饱和化合物的原位环氧化，从而为有机合成提供了一种新的通用环氧化方法。
The lipase-catalyzed reactions of carboxylic acids and carboxylic acid esters with hydrogen peroxide are used to generate various peroxy acids at room temperature and without mineral acids. Whereas Novozym 435(R) will only be able to catalyze the conversion of free unbranched carboxylic acids to peroxy acids, alpha-methylsubstituted carboxylic acid ethylesters can be converted to peroxy acids by perhydrolysis using the same enzyme. These peroxy acids are used in-situ for the epoxidation of unsaturated compounds and thus a new versatile epoxidation method for organic synthesis is proposed.