Network-Based Approaches for Multi-omics Integration.
Network-Based Approaches for Multi-omics Integration.
复制标题
基于网络的多组学整合方法。
DOI：
10.1007/978-1-0716-0239-3_23
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发表时间：
2020
影响因子：
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通讯作者：
Guangyan Zhou;Shuzhao Li;J. Xia
中科院分区：
文献类型：
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作者：
Guangyan Zhou;Shuzhao Li;J. Xia
基于网络的方法正在迅速成为整合和解释不同组学数据集（包括代谢组学）的一种有前途的策略。本章第一节介绍了多组学整合的研究现状和主要概念。第二节概述了可用于创建生物网络的公共资源。第三部分描述了三种常见的应用场景，包括子网识别，基于网络的富集分析和系统代谢组学。第四部分介绍了层次社区网络分析的概念。第五部分讨论了不同的网络可视化工具。本章最后对多组学整合的未来前景进行了展望。
Network-based approach is rapidly emerging as a promising strategy to integrate and interpret different -omics datasets, including metabolomics. The first section of this chapter introduces the current progresses and main concepts in multi-omics integration. The second section provides an overview of the public resources available for creation of biological networks. The third section describes three common application scenarios including subnetwork identification, network-based enrichment analysis, and systems metabolomics. The section four introduces the concept of hierarchical community network analysis. The section five discusses different tools for network visualization. The chapter ends with a future perspective on multi-omics integration.