Morphometric Correlation of Impulsivity in Medial Prefrontal Cortex
Morphometric Correlation of Impulsivity in Medial Prefrontal Cortex
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DOI：
10.1007/s10548-012-0270-x
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发表时间：
2013-07-01
期刊：
影响因子：
2.7
通讯作者：
Strafella, Antonio P.
中科院分区：
文献类型：
--
作者：
Cho, Sang Soo;Pellecchia, Giovanna;Strafella, Antonio P.
冲动性是一种复杂的行为，由不同的领域组成，包括行为去抑制，风险决策和延迟折扣异常。为了研究个体冲动性水平与灰质体积之间的区域脑相关性，我们对34名年轻健康受试者进行了基于体素的形态相关性分析，使用Barratt冲动性量表-11和计算机化Kirby延迟折扣任务测量冲动性评分。VBM分析表明，冲动似乎依赖于皮质（内侧前额叶皮质和背外侧前额叶皮质）和皮质下（腹侧纹状体）结构的网络，强调了与日常生活中与奖励相关的决策相关的大脑网络作为正常健康人群中冲动的形态学生物标志物的重要性。虽然我们在健康志愿者中的结果可能不会直接延伸到病理条件，但它们提供了对前额叶/额叶-纹状体连接异常患者冲动行为机制的深入了解，例如药物滥用，病理性赌博，ADHD和帕金森病。
Impulsivity is a complex behaviour composed of different domains encompassing behavioural disinhibition, risky decision-making and delay discounting abnormalities. To investigate regional brain correlates between levels of individual impulsivity and grey matter volume, we performed voxel-based morphometric correlation analysis in 34 young, healthy subjects using impulsivity scores measured with Barratt Impulsivity Scale-11 and computerized Kirby's delay discounting task. The VBM analysis showed that impulsivity appears to be reliant on a network of cortical (medial prefrontal cortex and dorsolateral prefrontal cortex) and subcortical (ventral striatum) structures emphasizing the importance of brain networks associated with reward related decision-making in daily life as morphological biomarkers for impulsivity in a normal healthy population. While our results in healthy volunteers may not directly extend to pathological conditions, they provide an insight into the mechanisms of impulsive behaviour in patients with abnormalities in prefrontal/frontal-striatal connections, such as in drug abuse, pathological gambling, ADHD and Parkinson's disease.