iRGD-functionalized PEGylated nanoparticles for enhanced colon tumor accumulation and targeted drug delivery
iRGD-functionalized PEGylated nanoparticles for enhanced colon tumor accumulation and targeted drug delivery
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iRGD 功能化聚乙二醇化纳米颗粒可增强结肠肿瘤积累和靶向药物输送
DOI：
10.2217/nnm-2017-0107
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发表时间：
2017-08-01
期刊：
影响因子：
5.5
通讯作者：
Merlin, Didier
中科院分区：
文献类型：
--
作者：
Ma, Lijun;Chen, Qiubing;Merlin, Didier
Aim: To enhance the tumor accumulation and targeted drug delivery for colon cancer therapy, iRGD peptide was introduced to the surface of PEGylated camptothecin-loaded nanoparticles (NPs). Methods: Cellular uptake, targeting specificity, bio-distribution and antitumor capacity were evaluated. Results: The functionalization of iRGD facilitated tumor accumulation and cellular uptake of NPs by Colon-26 cells. Furthermore, the resultant iRGD-PEG-NPs remarkably improved the therapeutic efficacy of camptothecin in vitro and in vivo by inducing a higher degree of tumor cell apoptosis compared with PEG-NPs. Conclusion: iRGD-PEG-NP is a desired drug delivery system to facilitate the drug accumulation in orthotopic colon tumor tissues and further drug internalization by colon cancer cells.
