ELECTROENCEPHALOGRAPHIC AND BEHAVIOURAL CORRELATES OF AN INSTRUMENTAL REWARD CONDITIONED RESPONSE IN RABBITS - PHYSIOLOGICAL AND PHARMACOLOGICAL STUDY
ELECTROENCEPHALOGRAPHIC AND BEHAVIOURAL CORRELATES OF AN INSTRUMENTAL REWARD CONDITIONED RESPONSE IN RABBITS - PHYSIOLOGICAL AND PHARMACOLOGICAL STUDY
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DOI：
10.1016/0013-4694(62)90052-4
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发表时间：
1962-01-01
期刊：
影响因子：
--
通讯作者：
LONGO, VG
中科院分区：
文献类型：
--
作者：
SADOWSKI, B;LONGO, VG
在家兔体内建立了一种工具性奖赏条件反应（ICR）。训练动物在蜂鸣器发出声音时用嘴拉动环，以获得一块食物。用慢性植入电极记录大脑皮层、海马和丘脑的电活动。ICR对胆碱能药物非常敏感。小剂量东莨菪碱（0.1 mg/kg i. v.）但并不影响食物的摄入。该操作伴随着跟踪的同步。Eserine恢复了测试的性能以及EEG激活模式。氯丙嗪和丙咪嗪仅在产生运动障碍的剂量下才有阻滞作用。特别是使用氯丙嗪时，未影响非条件性摄食。安非他明有两种作用。在低剂量下，它对ICR产生易化作用。在较高剂量下，发生了环的拉动，但随后没有从喂食杯中进食。麦角酰二乙胺在延长ICR的性能方面具有与苯丙胺相似的效果。目前的工作表明，对条件行为和EEG的同时研究可能有助于解释药物中枢作用的一些更精细的细节。
In rabbits an instrumental reward conditioned response (ICR) was established. The animals were trained to pull a ring with the mouth upon the sound of a buzzer in order to obtain a piece of food. The electrical activity of the cerebral cortex, the hippocampus and the thalamus was recorded by means of cronically implanted electrodes. The ICR was found to be very sensitive to cholinergic drugs. Small doses of scopolamine (0.1 mg/kg i.v.) abolished it, but did not interfere with the food intake. This actions was accompanied by synchronization of the tracing. Eserine restored the performance of the test as well as the EEG activation patterns. Chlorpromazine and imipramine eserted a blocking effect only in doses producing motor disturbances. Particularly with chlorpromazine, the unconditioned food intake was not disturbed. Amphetamine had two effects. In lower doses it exerted a facilitatory effecton the ICR. With higher doses the pulling of the ring occurred but was not followed by taking the food from the feeding cup. Lysergic acid diethylamide had an effect similar to that of amphetamine in prolonging the performance of the ICR. The present work demonstrates that the simultaneous study of conditioned behaviour and the EEG may be useful to explain some finer details of the central action of drugs.