Analysis of over-the-counter dietary supplements
Analysis of over-the-counter dietary supplements
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DOI：
10.1097/00042752-200110000-00008
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发表时间：
2001-10-01
影响因子：
2.7
通讯作者：
Starcevic, B
中科院分区：
文献类型：
--
作者：
Green, GA;Catlin, TH;Starcevic, B
目的：为了确定是否含有类固醇的非处方（OTC）膳食补充剂符合1994年膳食补充剂健康和教育法案（DSHEA）的标签要求：随机选择12个品牌的OTC补充剂，含有8种不同的类固醇，在商店购买，迎合运动员。有两种雄烯二酮（4-和5-雄烯-3，17-二酮），两种雄烯二醇（4-和5-雄烯-3 β，17 β-二醇），还有4种是19-去甲同源物（19-去甲-4-和5-雄甾烯-3，17-二酮和19-去甲-4-和5-雄甾烯-3 β，17 β-二醇）。12个品牌的OTC合成代谢雄激素补充剂进行了分析，通过高压液相色谱法。结果：我们发现，11 12个品牌的测试不符合1994年膳食补充剂健康和教育法规定的标签要求。一个品牌包含10毫克的睾酮，控制类固醇，另一个包含77%以上的标签所述，和11的12个包含少于所述的量在标签上。结论：这些错误的标签问题表明，本文研究的膳食类固醇补充剂的标签不能信任的内容和纯度信息。此外，许多体育组织禁止OTC类固醇;因此，使用它们的运动员有尿检结果阳性的风险。在这篇文章中，我们提供了分析的细节，类固醇的名称和结构的总结，以及关于阳性测试结果的性质的信息。运动员和他们的医生需要这些信息，因为潜在的医疗后果和积极的尿检结果。
Objective: To determine if steroids containing over-the-counter (OTC) dietary supplements conform to the labeling requirements of the 1994 Dietary Supplement Health and Education Act (DSHEA).Design: 12 brands of OTC supplements containing 8 different steroids were randomly selected for purchase in stores that cater to athletes. There are two androstenediones (4- and 5-androstene-3,17-dione), two androstenediols (4- and 5-androstene-3 beta, 17 beta -diol), and 4 more are 19-nor cogeners (19-nor-4-and 5-androstene-3,17-dione and 19-nor-4- and 5-androstene-3 beta, 17 beta -diol).Main Outcome Measures: 12 brands of OTC anabolic-androgenic supplements were analyzed by high-pressure liquid chromatography.Results: We found that 11 of 12 brands tested did not meet the labeling requirements set out in the 1994 Dietary Supplement Health and Education Act. One brand contained 10 mg of testosterone, a controlled steroid, another contained 77% more than the label stated, and 11 of 12 contained less than the amount stated on the label.Conclusions: These mislabeling problems show that the labels of the dietary steroid supplements studied herein cannot be trusted for content and purity information. In addition, many sport organizations prohibit OTC steroids; thus, athletes who use them are at risk for positive urine test results. In this article we provide the details of the analyses, a summary of the steroids by name and structure, and information on the nature of the positive test results. Athletes and their physicians need this information because of the potential medical consequences and positive urine test results.