Pilot evaluation of the efficacy of shampoo treatment with ultra-pure soft water for canine pruritus
Pilot evaluation of the efficacy of shampoo treatment with ultra-pure soft water for canine pruritus
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超纯软水洗发水治疗犬瘙痒症的效果中试评价
DOI：
10.1111/j.1365-3164.2010.00900.x
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发表时间：
2010
期刊：
影响因子：
1.4
通讯作者：
Matsuda H.
中科院分区：
文献类型：
--
作者：
Ohmori K;Tanaka A;Makita Y;Takai M;Yoshinari;Y;Matsuda H.
超纯软水是一种利用阳离子交换树脂将钙和镁离子置换为钠离子的水。我们最近在一种人类特应性皮炎的小鼠模型NC/NgaTnd小鼠中证明了用肥皂和UPSW洗涤可以降低皮炎的临床严重程度，并改善皮肤屏障功能。这项初步研究的目的是评估UPSW洗发水治疗犬瘙痒的疗效。11只有瘙痒症的狗被随机分成两组，根据它们是否每周接受UPSW或自来水洗发水治疗4 周。经过一段时间的洗涤后，治疗方案被改变，以便每只狗都接受两种治疗。比较治疗前和治疗后的值：所有者评估的瘙痒评分；调查人员记录的皮炎评分；以及经皮水分丢失(TEWL)。使用UPSW的洗发水治疗显著降低了狗的瘙痒和皮炎评分，而使用自来水的洗发水治疗则没有。此外，使用UPSW但不使用自来水的洗发水处理显著降低了狗的TEWL。在狗身上没有观察到由于治疗而引起的不良事件。此外，我们发现，局部应用UPSW治疗健康犬因胶带剥离引起的屏障破坏皮肤，比局部使用自来水更快地降低TEWL。我们的发现表明，使用UPSW的洗发水治疗可以促进皮肤屏障的恢复，因此可以被认为是治疗犬瘙痒和皮炎的一种可能的治疗选择。
Ultrapure soft water (UPSW) is water in which calcium and magnesium ions have been replaced with sodium ions using a cation‐exchange resin. We recently demonstrated that washing with soap and UPSW reduced the clinical severity of dermatitis and improved the skin barrier function in NC/NgaTnd mice, a murine model for human atopic dermatitis. The purpose of this pilot study was to evaluate the efficacy of shampoo treatment with UPSW for dogs with pruritus. Eleven dogs with pruritus were randomly assigned to two groups depending on whether they received weekly shampoo treatment with UPSW or tap water for 4 weeks. After a washout period, the treatment protocol was switched such that each dog received both treatments. The pre‐treatment and post‐treatment values of the following were compared: pruritus scores assessed by the owners; dermatitis scores recorded by an investigator; and transepidermal water loss (TEWL). Shampoo treatment with UPSW significantly decreased pruritus and dermatitis scores in the dogs, whereas shampoo treatment with tap water did not. In addition, shampoo treatment with UPSW, but not with tap water, significantly reduced TEWL in the dogs. Adverse events due to the treatment were not observed in the dogs. Furthermore, we found that topical application of UPSW for barrier‐disrupted skin caused by tape stripping in healthy dogs decreased TEWL more rapidly than topical application of tap water. Our findings suggest that shampoo treatment with UPSW promotes skin barrier recovery and thus could be considered as a possible therapeutic option in the management of pruritus and dermatitis in dogs.