The language of histone crosstalk.

The language of histone crosstalk.
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DOI:
10.1016/j.cell.2010.08.011
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发表时间:
2010-09-03
期刊:
影响因子:
64.5
通讯作者:
Shilatifard A
Shilatifard A
中科院分区:
生物学1区
文献类型:
--
作者:
Lee JS;Smith E;Shilatifard A

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有人认为,组蛋白翻译后修饰的特定模式及其串扰可能构成决定转录结果的代码。然而,最近的研究表明,组蛋白修饰具有上下文依赖的影响,使它们的相互作用更像染色质信号通路中的语言,而不是密码。
It has been suggested that a specific pattern of histone posttranslational modifications and their crosstalk may constitute a code that determines transcriptional outcomes. However, recent studies indicate that histone modifications have context-dependent effects, making their interplay more like a language within the chromatin signaling pathway than a code.
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