STUDIES ON THE MECHANISM OF ACTION OF THE CHLORINATED DIBENZO‐p‐DIOXINS AND RELATED COMPOUNDS *
STUDIES ON THE MECHANISM OF ACTION OF THE CHLORINATED DIBENZO‐p‐DIOXINS AND RELATED COMPOUNDS *
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氯化二苯并对二恶英及相关化合物的作用机制研究*
DOI：
10.1111/j.1749-6632.1979.tb56603.x
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发表时间：
1979
影响因子：
5.2
通讯作者：
A. Kende
中科院分区：
文献类型：
--
作者：
A. Poland;W. Greenlee;A. Kende
(TCDD)§和结构相关的氯代芳烃对芳烃羟基酶(AHH)活性的诱导：(2)综述存在介导该酶活性诱导的立体特异性识别位点的证据；(3)比较与该受体结合的构效关系和这些氯代芳烃的毒性的构效关系；(4)建议这些化合物毒性作用的模型。卤代芳烃(卤代二苯并对二恶英、二苯并呋喃、偶氮和偶氮苯以及联苯)的毒理学在本次研讨会的其他地方进行了综述；然而，首先总结其中的一些影响是有用的，以便我们在本报告中使用毒性一词时有一个共同的理解。TCDD被选为原型化合物，因为它是最有效和最深入的研究对象。TCDD对实验动物和人类产生多种毒性效应。TCDD在不同物种中产生的组织病理学反应在数量和质量上都有所不同，在某种程度上，急性给药与长期给药不同。(1)致死性。死因尚不清楚。豚鼠对物种的敏感性有一个顺序，鸡非常敏感，大鼠居中，小鼠表现出较低的敏感性。紧随其后的是
(TCDD) § and structurally related chlorinated aromatic hydrocarbons, the induction of aryl hydrocarbon hydroxylase (AHH) activity:(2) to review the evidence that there is a stereospecific recognition site which mediates the induction of this enzyme activity;(3) to compare the structure activity relationship for binding to this receptor and the structure activity relationship for the toxicity of these chlorinated aromatic hydrocarbons; and (4) to suggest a model for the mechanism of the toxic action of these compounds.The toxicology of the halogenated aromatic hydrocarbons (the halogenated dibenzo-p-dioxins, dibenzofurans, azo-and azoxybenzenes, and biphenyls) is reviewed elsewhere in this symposium; however, it is useful to summarize some of these effects first so that we share a common understanding when the term toxicity is used in this report. TCDD was selected as the prototype compound, because it is the most potent and the most thoroughly studied. TCDD produces a variety of toxic effects in laboratory animals and human beings. The histopathologic responses produced by TCDD differ quantitatively and qualitatively in different species and to some extent in acute versus chronic administration.(1) Lethality. The cause of death remains unknown. There is an order of species sensitivity with guinea pigs, and chickens being very sensitive, rats intermediate, and mice showing less sensitivity. Following the