Multi-components of evoked-brain potentials in deficit and nondeficit schizophrenia
Multi-components of evoked-brain potentials in deficit and nondeficit schizophrenia
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DOI：
10.1111/appy.12030
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发表时间：
2013-06-01
影响因子：
3.5
通讯作者：
Li, Tao
中科院分区：
文献类型：
--
作者：
Li, Zhe;Zheng, Bo;Li, Tao
本研究旨在检测缺陷型精神分裂症（DS）和非缺陷型精神分裂症（NDS）患者脑诱发电位（EBPS）相关的特异性和共同损害指标，并探讨EBPS与临床变量的关系。方法应用电子束诱发电位（EBPs）对21例DS、38例NDS和50例健康对照者（HC）进行P300波、失匹配负波（MMN）、感觉门控（SG）P50和关联性负变（CNV）检测。三组的比较和EBP与临床变量之间的关系分别采用一般线性模型分析和偏相关分析。结果与HCs相比，两组HCs均表现出N1、N2和P3 a潜伏期延迟，N1和N2波幅降低。MMN潜伏期延迟。P50比值和抑制比值受损，而SG损失率增加。CNV振幅降低。与HC相比，NDS组CNV的S2-C潜伏期延迟，DS组缩短。在CNV中，仅NDS与HC相比P3 b潜伏期延迟，仅DS与HC相比A点潜伏期延迟。DS的CNV中A点的潜伏期与较差的功能量表总体评估（6周）相关，并且与临床特征无关。讨论精神分裂症是一种临床综合征，具有共同的脑功能障碍，而DS是一个相对同质的精神分裂症亚组，具有独特的病理生理变化。
Introduction The present study aims to detect the specific and common impairment index relative to evoked brain potentials (EBPS) in deficit schizophrenia (DS) and nondeficit schizophrenia (NDS), and investigates the relationship between EBPs and clinical variables. Methods The study used EBPs in 21 patients with DS, 38 patients with NDS, and 50 healthy controls (HCs) to investigate P300 waves, mismatch negative (MMN), sensory gating (SG) P50 and contingent negative variation (CNV). A comparison of three groups and the relationship between EBPs and clinical variables were performed using general linear model analyses and partial correlation, respectively. Results Compared with HCs, both groups of patients showed delayed N1, N2, and P3a latency, and reduced N1 and N2 amplitude. The MMN showed delayed latency. The P50 ratios and the inhibited ratios were impaired, whereas SG loss ratios increased. CNV amplitude was reduced. Compared with HCs, NDS showed delayed latency of S2-C in CNV, whereas DS showed shortened latency. Only NDS, when compared with HCs, showed delayed latency of P3b, Also, only DS, when compared with HCs, showed delayed latency of point A in CNV. Latency of point A in CNV of DS, correlated with a poorer Global Assessment of Functioning Scale (6 weeks) and was independent of clinical characteristics. Discussion Schizophrenia represents a clinical syndrome with shared impairments in brain function, whereas DS is a relatively homogeneous subgroup of schizophrenia with unique pathophysiological changes.