Correlation between rCBF and speech perception in cochlear implant users
Correlation between rCBF and speech perception in cochlear implant users
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DOI：
10.1016/s0385-8146(99)00009-7
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发表时间：
1999-07-01
影响因子：
1.7
通讯作者：
Honjo, Iwao
中科院分区：
文献类型：
--
作者：
Fujiki, Nobuya;Naito, Yasushi;Honjo, Iwao
目的：虽然人工耳蜗（CI）为双耳聋人提供了恢复听力能力的机会，但 CI 用户的言语感知表现差异很大。为了阐明处理 CI 编码的语音信号的皮层机制，我们通过 PET 评估了 CI 用户言语激活期间的大脑活动与言语感知之间的相关性。方法：对 14 名语后聋 CI 用户进行了检查。患者使用的CI是22通道系统，其语音编码策略是Nucleus谱峰（SPEAK）策略。为了评估语音感知性能，我们检查了日语中的元音感知、辅音感知和语音跟踪性能。在无声音刺激和语音刺激期间测量区域脑血流量（rCBF）。从言语刺激的 PET 数据中减去沉默条件下的 PET 数据以确定 rCBF 的变化。在寻找听觉处理区域中 rCBF 的变化时，选择了三个感兴趣区域 (ROI)；初级听觉区、听觉关联区和布罗卡区。使用 Pearson 相关系数分析 ROI 中的 rCBF 变化与语音感知性能之间的相关性。结果：患者的言语感知表现变化很大。虽然言语感知与初级听觉区和布罗卡区的rCBF增加之间没有显着相关性，但在听觉关联区却存在正相关性。在左侧听觉关联区，元音感知表现的相关系数为0.546（P < 0.05），语音跟踪测试的相关系数为0.657（P < 0.05）。关于辅音感知表现，相关系数为0.743（P < 0.01）。仅右听觉关联区的辅音知觉表现与rCBF增加呈正相关（R=0.576，P<0.05）。这些相关性在左半球比在右半球更强。结论：采用 SPEAK 策略的 CI 用户语音听觉处理的改善伴随着听觉关联区更多神经元的招募。成人听觉皮层可能仍然具有可塑性或重组能力。此外，左半球可能比右半球更多地参与言语感知。
Objective: Although cochlear implants (CIs) have provided the opportunity for bilaterally deaf individuals to recover their hearing abilities, the speech perception performances of the CI users varies considerably. To elucidate the cortical mechanisms of processing speech signals coded by CIs, we evaluated the correlation between the brain activity during speech activation and speech perception in CI users by PET. Methods: Fourteen postlingually deaf CI users were examined. CI used in the patients was a 22-channel system and its speech-coding strategy was the Nucleus spectral peak (SPEAK) strategy. To evaluate the speech perception performances, we examined vowel perception, consonant perception and speech tracking performances in the Japanese language. Regional cerebral blood flow (rCBF) was measured during no sound stimulation and speech sound stimulation. PET data of the silent condition was subtracted from that of speech stimulation to determine changes in rCBF. In the search for changes in rCBF in the areas for auditory processing, three regions of interest (ROI) were selected; primary auditory area, auditory association area and Broca's area. The correlation between the rCBF changes in the ROIs and the speech perception performances was analyzed using Pearson's correlation coefficient. Results: The patient's speech perception performances ranged widely. Although there were no significant correlations between the speech perception and the rCBF increases in the primary auditory area and Broca's area, there were positive correlations in the auditory association area. In the left auditory association area, the correlation coefficient of the vowel perception performance was 0.546 (P < 0.05) and that of the speech-tracking test was 0.657 (P < 0.05). Regarding the consonant perception performance, the correlation coefficient was 0.743 (P < 0.01). There was a positive correlation only between the consonant perception performance and the rCBF increase (R = 0.576, P< 0.05) in the right auditory association area. These correlations are stronger in the left hemisphere than in the right hemisphere. Conclusions: It is suggested that the improvement of the auditory processing of speech in CI users with SPEAK strategy is accompanied by the recruitment of more neurons in the auditory association areas. The adult auditory cortices may still have plasticity or ability of reorganization. In addition, the left hemisphere may be more involved in speech perception than the right hemisphere.