Well‐Defined Poly(ethylene glycol) Hydrogels with Enhanced Mechanical Performance Prepared by Thermally Induced Copper‐Catalyzed Azide–Alkyne Cycloaddition
Well‐Defined Poly(ethylene glycol) Hydrogels with Enhanced Mechanical Performance Prepared by Thermally Induced Copper‐Catalyzed Azide–Alkyne Cycloaddition
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DOI：
10.1002/mame.201600222
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发表时间：
2016-11
影响因子：
3.9
通讯作者：
Kewen Li;L. Cen;Chao Zhou;Aokai Zhang;F. Yao;L. Tan;L. Xu;G. Fu
中科院分区：
文献类型：
--
作者：
Kewen Li;L. Cen;Chao Zhou;Aokai Zhang;F. Yao;L. Tan;L. Xu;G. Fu
聚乙二醇（PEG）基水凝胶由于其良好的生物相容性和低廉的成本，近年来受到越来越多的关注。然而，由传统方法制备的PEG基水凝胶由于其无序的网络结构而表现出较差的可加工性。在此，通过简单的热诱导的铜催化的叠氮化物-炔环加成（CuAAC）反应，明确的PEG基水凝胶的制备被证明。为了实现这一点，采用热化学还原的Cu（I）催化剂来触发“点击”交联，从而产生明确定义的PEG网络。所合成的PEG基水凝胶具有良好的机械性能，拉伸强度为2.51 MPa，这高于由CuSO 4/NaAc介导或CuBr/配体催化的CuAAC制备的传统PEG基水凝胶。此外，体外细胞毒性和体内猪皮下植入试验表明，合成的PEG基水凝胶具有良好的生物相容性和低毒性，使其成为一个有前途的候选人，在生物医学设备和组织工程的应用。
Poly(ethylene glycol) (PEG)-based hydrogels have attracted increasing attention in recent years due to their good biocompatibility and low cost. However, the PEG-based hydrogels prepared by traditional methods exhibit a poor machinability due to their disordered network structure. Herein, the preparation of well-defined PEG-based hydrogel via a facile thermally induced copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction is demonstrated. To accomplish this, thermochemically reduced Cu(I) catalyst is adopted to trigger “click” cross-linking, resulting in a well-defined PEG network. The as-synthesized PEG-based hydrogel exhibits good mechanical performance with a tensile strength of 2.51 MPa, which is higher than the traditional PEG-based hydrogels prepared from CuSO4/NaSac-mediated or CuBr/ligand-catalyzed CuAAC. Moreover, in vitro cytotoxicity and in vivo porcine subcutaneous implantation tests demonstrate that the as-synthesized PEG-based hydrogel has a good biocompatibility and low toxicity, making it a promising candidate for the applications in biomedical devices and tissue engineering.