Poor Oral Health Linked with Higher Risk of Alzheimer's Disease.
Poor Oral Health Linked with Higher Risk of Alzheimer's Disease.
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口腔健康状况不佳与阿尔茨海默病的较高风险有关。
DOI：
10.3390/brainsci13111555
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发表时间：
2023-11-07
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
--
作者：
阿尔茨海默病（AD）是一种多因素的神经退行性疾病，其特征在于老年人的认知和行为改变。新出现的证据表明，口腔健康状况不佳与AD有关，但缺乏大规模的临床研究证明这种联系。在本文中，我们使用TriNetX数据库来生成临床队列，并在> 3000万口腔健康正常（n = 31，418，814）和口腔健康不良（n = 1，232，751）的去识别受试者中评估AD的风险和生存率。与口腔健康正常组相比，口腔健康不良组的AD风险增加了两倍以上（风险比（RR）：2.363，（95%置信区间：2.326，2.401））。为了减少潜在的偏倚，我们对年龄、性别和多个实验室指标进行了回顾性倾向评分匹配。匹配后，队列的生存概率没有显着差异。此外，当比较多种口腔疾病时，与牙齿脱落相关的疾病是AD最显著的危险因素（RR：3.186，（95% CI：3.007，3.376））。我们的研究结果表明，口腔健康可能是重要的AD风险，无论年龄，性别或实验室测量。然而，需要更多的大规模队列研究来验证这些发现，并进一步评估口腔健康与AD之间的联系。
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease characterized by cognitive and behavioral changes in older adults. Emerging evidence suggests poor oral health is associated with AD, but there is a lack of large-scale clinical studies demonstrating this link. Herein, we used the TriNetX database to generate clinical cohorts and assess the risk of AD and survival among >30 million de-identified subjects with normal oral health (n = 31,418,814) and poor oral health (n = 1,232,751). There was a greater than two-fold increase in AD risk in the poor oral health cohort compared to the normal oral health group (risk ratio (RR): 2.363, (95% confidence interval: 2.326, 2.401)). To reduce potential bias, we performed retrospective propensity score matching for age, gender, and multiple laboratory measures. After matching, the cohorts had no significant differences in survival probability. Furthermore, when comparing multiple oral conditions, diseases related to tooth loss were the most significant risk factor for AD (RR: 3.186, (95% CI: 3.007, 3.376)). Our results suggest that oral health may be important in AD risk, regardless of age, gender, or laboratory measures. However, more large-scale cohort studies are necessary to validate these findings and further evaluate links between oral health and AD.
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影响因子：
5
作者：
Ishida N;Ishihara Y;Ishida K;Tada H;Funaki-Kato Y;Hagiwara M;Ferdous T;Abdullah M;Mitani A;Michikawa M;Matsushita K
通讯作者：
Matsushita K
影响因子：
6.8
作者：
Huang, Jinghan;Tao, Qiushan;Ang, Ting Fang Alvin;Farrell, John;Zhu, Congcong;Wang, Yixuan;Stein, Thor D.;Lunetta, Kathryn L.;Massaro, Joseph;Mez, Jesse;Au, Rhoda;Farrer, Lindsay A.;Qiu, Wei Qiao;Zhang, Xiaoling
通讯作者：
Zhang, Xiaoling
DOI：
10.3390/ijerph18094889
发表时间：
2021-05-04
影响因子：
--
作者：
Han SJ;Son YJ;Kim BH
通讯作者：
Kim BH
影响因子：
11
作者：
Beydoun, May A.;Beydoun, Hind A.;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
4.8
作者：
Farquhar, Douglas R.;Divaris, Kimon;Olshan, Andrew F.
通讯作者：
Olshan, Andrew F.