Fundus Autofluorescence of Elongated Photoreceptor Outer Segments in Central Serous Chorioretinopathy
Fundus Autofluorescence of Elongated Photoreceptor Outer Segments in Central Serous Chorioretinopathy
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DOI：
10.1016/j.ajo.2010.09.031
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发表时间：
2011-04-01
影响因子：
4.2
通讯作者：
Mukai, Ryo
中科院分区：
文献类型：
--
作者：
Matsumoto, Hidetaka;Kishi, Shoji;Mukai, Ryo
目的：探讨中心性浆液性脉络膜视网膜病变(CSC)的眼底自发荧光(AF)模式的来源。设计：回顾性、观察性病例系列。方法：对30例(30只眼)原发CSC患者的眼底自发荧光(AF)和光谱域光学相干断层扫描(SD-OCT)进行回顾性研究。结果：22只眼(73%)黄斑区房颤呈斑块状增加，中心凹中心凹的光感受器外段长度较对侧长(P=.06)。有沉淀物的17只眼，房颤点状增多，与检眼镜下的沉淀物相对应。伴有明显浆液性视网膜脱离(SRD)的眼房颤显著降低(P=.017)。8只眼(27%)下部SRD的房颤增加。结论：斑片状增加的房颤似乎起源于脱离的视网膜中延长的Ro受体外段。来自感光细胞外节的自体荧光团可能集中在沉淀物中，也可能已稳定在下方的SRD中。《眼科杂志》2011；151：617-623。(C)2011年由Elsevier Inc.保留所有权利。)
PURPOSE: To determine the origin of fundus autofluorescence (AF) patterns in central serous chorioretinopathy (CSC).DESIGN: Retrospective, observational case series.METHODS: We retrospectively studied 30 consecutive eyes of 30 patients with primary CSC using AF and spectral-domain optical coherence tomography (SD-OCT). We measured the AF using the Heidelberg Retina Angiograph with a 488-nn excitation light and a 500-nm cutoff barrier filter and compared the AF patterns with ophthalmoscopy and SD-OCT.RESULTS: We observed a patchy increased AF in the macular area in 22 eyes (73%), in which the length of the photoreceptor outer segment at the central fovea tended to be longer than the other eyes (P = .06). The punctate increased AF corresponded to the ophthalmoscopic precipitates in 17 eyes with precipitates. AF significantly (P = .017) decreased in eyes with a prominent serous retinal detachment (SRD). Eight eyes (27%) had increased AF in the inferior SRD.CONCLUSIONS: The patchy increased AF appears to originate from elongated rhotoreceptor outer segments in the detached retina. The autofluorescent fluorophores from the photoreceptor outer segments may be concentrated in precipitates or have settled into the inferior SRD. (Am J Ophthalmol 2011;151:617-623. (C) 2011 by Elsevier Inc. All rights reserved.)