Reticulated platelet monitoring after autologous peripheral haematopoietic progenitor cell transplantation
Reticulated platelet monitoring after autologous peripheral haematopoietic progenitor cell transplantation
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DOI：
10.1016/j.transci.2009.03.018
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发表时间：
2009-06-01
影响因子：
1.9
通讯作者：
Crovetti, Giovanni
中科院分区：
文献类型：
--
作者：
Martinelli, Giovanna;Merlo, Patrizia;Crovetti, Giovanni
网状血小板是巨核细胞生成最年轻的标志物。我们监测了13例接受自体外周血造血祖细胞移植的血液病患者。我们使用了基于噻唑橙子血小板染色的流式细胞术方法。患者在血小板计数最低点前平均5天出现网织血小板百分比下降。在所有情况下，血小板恢复之前，网织血小板的上升，在10例患者接受血小板预防性输注后RP上升。网织血小板的增加是移植的早期迹象，可能是移植患者输血管理的一个简单参数。(C)2009爱思唯尔有限公司保留所有权利。
Reticulated platelets are the youngest marker of megakaryopoiesis. We monitored 13 haematological patients undergoing autologous peripheral haematopoietic progenitor cell transplantation. We used a flow cytometric method based on thiazole orange platelet staining. Patients showed a fall in reticulated platelet percentage at a mean of 5 days before a nadir of the platelet count. In all cases, platelet recovery is preceded by a rise of reticulated platelets; in 10 cases patients received platelet prophylactic transfusions after RP rise. The rise in reticulated platelets is an early sign of engraftment and may represent an easy parameter for transfusion management of transplanted patients. (C) 2009 Elsevier Ltd. All rights reserved.