Periconceptional Undernutrition Alters Growth Trajectory and Metabolic and Endocrine Responses to Fasting in Late-Gestation Fetal Sheep
Periconceptional Undernutrition Alters Growth Trajectory and Metabolic and Endocrine Responses to Fasting in Late-Gestation Fetal Sheep
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DOI：
10.1203/01.pdr.0000155942.18096.9c
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发表时间：
2005-04
影响因子：
3.6
通讯作者：
M. Oliver;P. Hawkins;J. Harding
中科院分区：
文献类型：
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作者：
M. Oliver;P. Hawkins;J. Harding
母亲在怀孕期间营养不良会导致出生后后代的代谢调节受损。这种异常在妊娠早期确定的程度，以及可能在胎儿生命中已经存在的程度尚不清楚。我们研究了妊娠晚期围产期营养不良对胎儿生长和代谢的影响。母羊在整个妊娠期间被良好喂养（N）或营养不良，从交配前61天到交配后30天（UN），母羊体重减少15%。在第121天，将一组母羊及其单胎胎儿（N，n = 10; UN，n = 10）禁食72 h，在8 h内静脉注射25 g葡萄糖，然后再喂食。胎仔和胎盘重量在131 d时无差异。UN母羊有较高的葡萄糖，氨基氮，血红蛋白浓度比N母羊。联合国胎儿有较高的葡萄糖和乳酸，和较低的氨基氮和O2浓度和pH值。联合国母羊有较高的胰岛素和较低的IGF-I浓度，和联合国母羊和胎儿有较高的胎盘催乳素浓度。研究第二个队列（N，n = 8; UN，n = 10）直至足月。联合国胎儿的胸围增量减少，直到分娩，但出生体重没有显着减少。这些结果表明，胎儿的生长，代谢和内分泌状态，并在妊娠后期胎盘功能的影响，母亲的营养在围受孕期，独立于胎儿的大小。母亲的代谢和内分泌适应可能会介导其中的一些影响。这种适应可能允许胎儿在面临潜在的不利营养环境时继续生长和存活。
Maternal undernutrition during pregnancy can lead to impaired metabolic regulation in postnatal offspring. The extent to which such abnormalities are determined in early gestation, and may already be present in fetal life, is unknown. We studied the effect of periconceptional undernutrition on fetal growth and metabolism in late gestation. Ewes were either well fed throughout pregnancy (N) or undernourished to reduce ewe weight by 15% from 61 d before until 30 d after mating (UN). At 121 d, one cohort of ewes and their singleton fetuses (N, n = 10; UN, n = 10) were fasted for 72 h, given 25 g of glucose i.v. over 8 h, and refed. Fetal and placental weights were not different at 131 d. UN ewes had higher glucose, amino nitrogen, and Hb concentrations than N ewes. UN fetuses had higher glucose and lactate, and lower amino nitrogen and O2 concentrations and pH. UN ewes had higher insulin and lower IGF-I concentrations, and UN ewes and fetuses had higher placental lactogen concentrations. A second cohort (N, n = 8; UN, n = 10) were studied until term. Chest girth increment was reduced in UN fetuses until delivery, but birth weights were not significantly reduced. These findings suggest that fetal growth, metabolic and endocrine status, and placental function in late gestation are influenced by maternal nutrition in the periconceptional period, independent of fetal size. Metabolic and endocrine adaptations in the mother may mediate some of these effects. Such adaptations may allow continued fetal growth and survival in the face of a potentially adverse nutritional environment.