Human epicardial fat: what is new and what is missing?
Human epicardial fat: what is new and what is missing?
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DOI：
10.1111/j.1440-1681.2011.05601.x
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发表时间：
2011-12-01
影响因子：
2.9
通讯作者：
Fain, John N.
中科院分区：
文献类型：
--
作者：
Sacks, Harold S.;Fain, John N.
1.人心外膜脂肪组织（EAT）的推定生理功能包括：（i）用于心肌能量需求的脂质储存;（ii）体温调节，由此EAT的棕色脂肪组分响应于核心冷却通过非颤抖性产热产生热量;（iii）心脏自主神经节和神经的神经保护;以及（iv）冠状动脉的血管运动和管腔尺寸的调节。在病理生理情况下，EAT可能在心律失常和脂毒性心肌病中发挥不良旁分泌作用，但目前主要关注的是其作为免疫器官促进冠状动脉疾病（CAD）周围炎症的假设作用。
1. Putative physiological functions of human epicardial adipose tissue (EAT) include: (i) lipid storage for the energy needs of the myocardium; (ii) thermoregulation, whereby brown fat components of EAT generate heat by non-shivering thermogenesis in response to core cooling; (iii) neuroprotection of the cardiac autonomic ganglia and nerves; and (iv) regulation of vasomotion and luminal size of the coronary arteries. Under pathophysiological circumstances, EAT may play an adverse paracrine role in cardiac arrhythmias and in lipotoxic cardiomyopathy, but of major current interest is its hypothetical role as an immunological organ contributing to inflammation around coronary artery disease (CAD).