Oncocytic mucoepidermoid carcinoma of the parotid gland: case report.
Oncocytic mucoepidermoid carcinoma of the parotid gland: case report.
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DOI：
10.1093/jscr/rjac039
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发表时间：
2022-03
影响因子：
0.5
通讯作者：
Alsayed A
中科院分区：
文献类型：
--
作者：
Alshammari A;Aljufairi E;Alsayed A
粘液表皮样癌是涎腺最常见的恶性肿瘤。嗜酸细胞变异是罕见的，细胞学上可能被误认为是良性肿瘤，如嗜酸细胞瘤和沃辛瘤。我们报告一位67岁女性患者，因左侧腮腺肿块而就诊，细胞学检查诊断为良性嗜酸细胞瘤。后来，患者接受左侧腮腺切除术，组织学检查显示恶性嗜酸性粘液表皮样癌。这些实体之间的区别对于患者获得适当的管理至关重要。单凭细胞学检查，很难鉴别;然而，组织学检查显示恶性特征，包括浸润性边界，淋巴管浸润和神经周围浸润，排除良性肿瘤。粘蛋白的存在是怀疑嗜酸性粘液表皮样癌的重要线索。由于嗜酸细胞粘液表皮样癌P63阳性且伴有MAML 2易位，因此辅助研究有助于正确诊断。
Mucoepidermoid carcinoma is the most common malignant tumour of salivary glands. Oncocytic variant is rare and could be mistaken for benign entities like oncocytoma and Warthin tumour on cytology. We present a case of a 67-year-old female presented with left parotid gland mass, which was diagnosed as a benign oncocytoma on cytologic examination. Later, the patient underwent left parotidectomy where the histologic examination revealed a malignant oncocytic mucoepidermoid carcinoma. The distinction between these entities is essential to get a proper management for the patient. On cytology alone, it is quite difficult to differentiate; however, histologic examination shows malignant features including infiltrative borders, lymphovascular invasion and perineural invasion excluding a benign tumour. The presence of mucin is an important clue to suspect oncocytic mucoepidermoid carcinoma. Ancillary studies can help reach a wright diagnose, as oncocytic mucoepidermoid carcinoma is positive for P63 and has MAML2 translocation.