ACUPUNCTURE-LIKE STIMULATION INDUCES A HETEROSEGMENTAL RELEASE OF MET-ENKEPHALIN-LIKE MATERIAL IN THE RAT SPINAL-CORD
ACUPUNCTURE-LIKE STIMULATION INDUCES A HETEROSEGMENTAL RELEASE OF MET-ENKEPHALIN-LIKE MATERIAL IN THE RAT SPINAL-CORD
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DOI：
10.1016/0304-3959(91)90013-n
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发表时间：
1991-10-01
期刊：
影响因子：
7.4
通讯作者：
LEBARS, D
中科院分区：
文献类型：
--
作者：
BING, Z;CESSELIN, F;LEBARS, D
为探讨针刺对脊髓脑啡肽能神经元活动的影响，在氟烷麻醉大鼠腰段或颈三叉神经区以0.1ml/min的速度灌流人工脑脊液，测定0.5ml灌流液中甲硫氨酸脑啡肽样物(MELM)的含量。将中医针灸医师在右后肢“足三里”穴进行手法针刺的效果与针刺“足三里”旁非穴位的效果进行比较。针刺“足三里”穴和非穴位均不影响MELM在腰部的释放，但显著增加了MELM在颈-三叉神经区的释放。结论：手法针刺可引起脊髓内脑啡肽能神经元的异位节段激活，并且这种作用在刺激点的位置上是非特异性的。
In order to investigate the effects induced by acupuncture on the activity of enkephalinergic neurons in the spinal cord, either the lumbar or the cervico-trigeminal area was perfused with artificial cerebrospinal fluid (CSF) (0.1 ml/min) in halothane-anaesthetized rats, and Met-enkephalin-like material (MELM) was measured in 0.5 ml fractions of the perfusates. The effects of manual acupuncture performed by a traditional Chinese acupuncturist at the 'Zusanli' point on the right hind limb were compared to the effects induced by acupuncture applied at a non-acupoint next to 'Zusanli'. The manipulation of needles either at the 'Zusanli' point or at the non-acupoint had no effect on the release of MELM from the lumbar area but significantly increased the release from the cervico-trigeminal zone. It is concluded that manual acupuncture triggers a heterosegmental activation of enkephalinergic neurones within the spinal cord and that this effect is non-specific in terms of the location of the stimulated point.