The effect of a hydro-alcoholic extract of olive fruit on reproductive argons in male sprague-dawley rat
The effect of a hydro-alcoholic extract of olive fruit on reproductive argons in male sprague-dawley rat
复制标题
DOI：
--
复制
发表时间：
2013-04
影响因子：
--
通讯作者：
P. Najafizadeh;F. Dehghani;Mohammadreza Panjeh Shahin;Sommaye Hamzei Taj
中科院分区：
文献类型：
--
作者：
P. Najafizadeh;F. Dehghani;Mohammadreza Panjeh Shahin;Sommaye Hamzei Taj
背景：橄榄(Olea Europe A)为木犀科植物，是一种植物雌激素化合物，含有木脂素和酚类化合物。一些研究表明，植物雌激素具有减少精子发生的作用。目的：研究橄榄果水乙醇提取物对雄性大鼠生殖功能的影响。材料和方法：分别以50、150、450 mg/kg剂量灌胃给药，连续48d。赋形剂组灌胃生理盐水，对照组(每组8只)不给予任何东西。49天后测定精子数、精子活力、前列腺、睾丸、附睾腺、精囊重量等生殖指标。结果：大鼠左侧睾丸重量、精囊重量、睾酮激素、精子数和精子活动率均显著降低，而前列腺癌、附睾腺重量和雌二醇量无明显变化。结论：橄榄提取物可能对生育因素有不良影响，经进一步研究可望作为男性避孕药。
Background: Olive (Olea europea), from the Oleaceae family, is known as a phytoestrogen plant compound, containing Lignans and phenoliccompounds. Some studies have shown phytoestrogens to have spermatogenesis-decreasing effects. Objective: The present study investigated the effects of a hydro-alcoholic extract of olive fruit on reproductive argons in male rats. Materials and Methods: The hydro-alcoholic olive (Olea europaea) extract was given orally to three experimental groups of rats in 50, 150, and 450 mg/kg in 48 days. The vehicle group was fed with normal saline and nothing was given to the control group (each group with 8 rats). After 49 days reproductive indicators i.e., sperm count, sperm motility, the weight of prostate, testis, epididymis, and seminal vesicle were measured. Results: The results showed a significant decrease in the weights of the left testicle, seminal vesicle, testosterone hormone, sperm count and sperm motility but there was no significant difference with regard to the weights of prostate and epididymis, and estradiol hormone. Conclusion: This study suggests that olive extract may have deleterious effects on fertility factors; therefore, after further studies, it may be used as a contraceptive in males.