Issues related to subgroup analysis in clinical trials.
Issues related to subgroup analysis in clinical trials.
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DOI：
10.1081/bip-120014565
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发表时间：
2002-08-01
影响因子：
1.1
通讯作者：
Tsong, Yi
中科院分区：
文献类型：
--
作者：
Cui, Lu;Hung, H M James;Tsong, Yi
亚组结果的解释是一项艰巨的任务。本文试图澄清亚组分析中的困惑，并就如何避免亚组结果解释中的错误给出一些实用的建议。我们认为，亚组结果的正确解释与亚组分析的内在统计性质和有效性密切相关。从统计学的角度对亚组分析进行系统的讨论将有助于临床试验从业人员。
Interpretation of subgroup findings is a difficult task. The attempt of this article is to clarify confusions on subgroup analysis and to give some practical suggestions on how to avoid mistakes in interpreting subgroup outcome. We believe that the correct interpretation of subgroup findings is closely related to the intrinsic statistical property and validity of the subgroup analysis. A systematic discussion on subgroup analysis from a statistical point of view will be helpful to clinical trial practitioners.