Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress
Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress
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DOI：
10.1179/147683008x301478
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发表时间：
2008-06-01
影响因子：
3.6
通讯作者：
Weiss, M.
中科院分区：
文献类型：
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作者：
Baumeister, J.;Barthel, T.;Weiss, M.
本研究旨在探讨磷脂酰丝氨酸（PS）对精神应激后认知功能和大脑皮层活动的影响。在熟悉后，16名健康受试者在测试-再测试设计（T1和T2）中完成诱导应激后的认知任务。在T1后，受试者直接双盲分配至PS组或安慰剂组，然后在42天后进行T2。在T1和T2时，皮质活动在基线和应激后立即使用脑电图（EEG）进行认知任务测量。在17个电极位置记录EEG，并在Theta、Alpha-1、Alpha-2、Beta-1和Beta-2处用快速傅立叶变换（FFT）确定功率。使用ANOVA（组x试验x时间）计算统计量。该研究的主要发现是，在诱导应激前后，长期补充磷脂酰丝氨酸显著降低了右半球额叶脑区（F8; P < 0.05）的β-1功率。与对照组相比，PS组中β-1功率的结果与更放松的状态有关。
The aim of this study was to investigate the effect of phosphatidylserine ( PS) on cognition and cortical activity after mental stress. After familiarization, 16 healthy subjects completed cognitive tasks after induced stress in a test-re-test design (T1 and T2). Directly after T1, subjects were assigned double-blind to either PS or placebo groups followed by T2 after 42 days. At T1 and T2, cortical activity was measured at baseline and immediately after stress with cognitive tasks using electro-encephalography ( EEG). EEG was recorded at 17 electrode positions and fast Fourier transforms (FFT) determined power at Theta, Alpha-1, Alpha-2, Beta-1 and Beta-2. Statistics were calculated using ANOVA ( group x trial x time). The main finding of the study was that chronic supplementation of phosphatidylserine significantly decreases Beta-1 power in right hemispheric frontal brain regions (F8; P < 0.05) before and after induced stress. The results for Beta-1 power in the PS group were connected to a more relaxed state compared to the controls.