Keeping lung surfactant where it belongs: Protein regulation of two-dimensional viscosity
Keeping lung surfactant where it belongs: Protein regulation of two-dimensional viscosity
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DOI：
10.1529/biophysj.104.052092
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发表时间：
2005-07-01
影响因子：
3.4
通讯作者：
Zasadzinski, JA
中科院分区：
文献类型：
--
作者：
Alonso, C;Waring, A;Zasadzinski, JA
肺表面活性剂导致肺泡中的表面张力g在呼气时下降至接近零;在上气道中，γ类似于30 mN/m并且是恒定的。因此，在肺泡和气道之间存在表面张力梯度，这将导致表面活性剂流出肺泡并消除表面张力梯度。然而，肺表面活性物质特异性蛋白SP-C通过调节单层中固体与流体相的比率来增强对表面活性物质流动的阻力，从而导致单层从流体状转变为固体状的堵塞转变。伴随的表面粘度的三个数量级的增加有助于最小化表面活性剂流到气道，并可能稳定肺泡以防塌陷。
Lung surfactant causes the surface tension, g, in the alveoli to drop to nearly zero on exhalation; in the upper airways gamma is similar to 30 mN/m and constant. Hence, a surface tension gradient exists between alveoli and airways that should lead to surfactant flow out of the alveoli and elimination of the surface tension gradient. However, the lung surfactant specific protein SP-C enhances the resistance to surfactant flow by regulating the ratio of solid to fluid phase in the monolayer, leading to a jamming transition at which the monolayer transforms from fluidlike to solidlike. The accompanying three orders of magnitude increase in surface viscosity helps minimize surfactant flow to the airways and likely stabilizes the alveoli against collapse.