Fibronectin. A new therapy for corneal trophic ulcer.
Fibronectin. A new therapy for corneal trophic ulcer.
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纤连蛋白。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
R. Manabe
中科院分区：
文献类型：
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作者：
T. Nishida;Y. Ohashi;T. Awata;R. Manabe
纤连蛋白是一种糖蛋白，存在于血浆和细胞外基质中，负责细胞粘附。我们使用亲和层析法纯化了两名常规治疗无效的营养性角膜溃疡和持续性上皮缺损患者的血浆纤维连接蛋白。自体纯化纤连蛋白滴眼液治疗后3天开始上皮再生，3周内上皮缺损完全消失。治疗结束后未观察到复发。通过修改原来的色谱程序，我们能够在两个小时内获得纯化的纤连蛋白，这使我们能够治疗门诊病人以及住院病人。
Fibronectin, a glycoprotein, is present in plasma and extracellular matrix and is responsible for cellular adhesion. With the use of affinity chromatography, we purified plasma fibronectin from two patients with trophic corneal ulcer and persistent epithelial defect after conventional therapy was ineffective. Reepithelialization began three days after initiation of treatment with autologous purified fibronectin eyedrops, and the epithelial defects disappeared completely within three weeks. No recurrence was observed after treatment ended. By modifying the original chromatographic procedure, we were able to obtain purified fibronectin in two hours, which allowed us to treat outpatients as well as inpatients.
纤连蛋白治疗兔角膜伤口。
DOI：
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发表时间：
1981
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
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作者：
Fujikawa,LS;Foster,CS;Harrist,TJ;Lanigan,JM;Colvin,RB
通讯作者：
Colvin,RB