Maternal and Fetal Immune Response to in Utero Stem Cell Transplantation.
Maternal and Fetal Immune Response to in Utero Stem Cell Transplantation.
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母体和胎儿对子宫内干细胞移植的免疫反应。
DOI：
10.1007/s40778-018-0129-5
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发表时间：
2018
影响因子：
1.4
通讯作者：
Shaaban,Aimen
中科院分区：
文献类型：
--
作者：
Alhajjat,Amir;Shaaban,Aimen
综述目的宫内造血细胞移植(IUHCT)是一种很有前途的干预措施，可用于先天性疾病的无毒治疗，其前提是胎儿免疫不成熟和不能排斥同种异体造血移植。然而，临床IUCHT失败了，除非胎儿的免疫功能严重受损。本文综述了来自胎儿或母体免疫系统的植入障碍的最新研究。最近的发现新的报告阐明了母体体液免疫和细胞免疫以及胎儿固有细胞免疫在同种异体IUHCT抵抗中的作用。这些实验发现启发了克服这些障碍的新方法。尽管取得了这些进展，但关于IUHCT的母体免疫屏障的假设并不能充分解释仅在母体免疫正常的胎儿免疫缺陷治疗中取得的临床成功。摘要异基因IUHCT的母婴免疫反应的特征为产前耐受的复杂性提供了新的见解。未来在这一领域的工作应该致力于为临床IUHCT的成功和失败的观察模式提供统一的解释。
Purpose of ReviewIn utero hematopoietic cellular transplantation (IUHCT) is a promising intervention for the non-toxic treatment of congenital disease that hinges on the assumption of fetal immunologic immaturity and an inability to reject a hematopoietic allograft. However, clinical IUCHT has failed except in cases where the fetus is severely immunocompromised. The current review examines recent studies of engraftment barriers stemming from either the fetal or maternal immune system.Recent FindingsNew reports have illuminated roles for maternal humoral and cellular immunity and fetal innate cellular immunity in the resistance to allogeneic IUHCT. These experimental findings have inspired new approaches to overcome these barriers. Despite these advances, postulates regarding a maternal immune barrier to IUHCT provide an inadequate explanation for the well-documented clinical success only in the treatment of fetal immunodeficiency with normal maternal immunity.SummaryCharacterization of the maternal and fetal immune response to allogeneic IUHCT provides new insight into the complexity of prenatal tolerance. Future work in this area should aim to provide a unifying explanation for the observed patterns of success and failure with clinical IUHCT.