Increased variability in reaction time is associated with amyloid beta pathology at age 70
Increased variability in reaction time is associated with amyloid beta pathology at age 70
复制标题
DOI：
10.1002/dad2.12076
复制
发表时间：
2020-01-01
影响因子：
5.3
通讯作者：
Crutch, Sebastian J.
中科院分区：
文献类型：
--
作者：
Lu, Kirsty;Nicholas, Jennifer M.;Crutch, Sebastian J.
我们研究了阿尔茨海默病病理的生命过程因素和神经成像生物标志物是否能预测老年人的反应时间（RT）表现。方法对46名1946年同一周出生的参与者（n = 501，评估时年龄69 ~ 71岁）进行了两项选择RT任务和淀粉样蛋白正电子发射断层扫描和磁共振成像。我们测试了任务结果（RT、错误率、RT的个体内变异性）与包括儿童认知能力和教育在内的生命历程预测因子之间的关联。在406名认知正常参与者的子样本中，我们调查了任务结果与包括a- β阳性在内的生物标志物之间的关系。结果认知正常的A β阳性受试者的可变RTs比A β阴性受试者多10%，尽管其平均RTs相似。儿童认知能力和教育对任务表现有独立的预测作用。本研究提供了新的证据，证明在认知正常的老年人中，当痴呆患病率仍然很低时，A β病理与RT一致性较差有关。
IntroductionWe investigated whether life-course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in older adults.MethodsInsight 46 study participants, all born in the same week in 1946 (n = 501; ages at assessment = 69 to 71 years), completed a 2-choice RT task and amyloid beta (A beta) positron emission tomography and MR imaging. We tested for associations between task outcomes (RT; error rate; intra-individual variability in RT) and life-course predictors including childhood cognitive ability and education. In a subsample of 406 cognitively normal participants, we investigated associations between task outcomes and biomarkers including A beta-positivity.ResultsCognitively normal A beta-positive participants had 10% more variable RTs than A beta-negative participants, despite having similar mean RTs. Childhood cognitive ability and education independently predicted task performance.DiscussionThis study provides novel evidence that A beta pathology is associated with poorer consistency of RT in cognitively normal older adults, at an age when dementia prevalence is still very low.