Endothelial injury and repair: A novel theory for atherosclerosis
Endothelial injury and repair: A novel theory for atherosclerosis
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DOI：
10.1177/0003319708320761
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发表时间：
2008-08-01
期刊：
影响因子：
2.8
通讯作者：
Pirro, Matteo
中科院分区：
文献类型：
--
作者：
Mannarino, Elmo;Pirro, Matteo
动脉粥样硬化是动脉壁内的一种病理性脂质沉积的传统观点已经被一个更复杂的理论重新定义，在这个理论中，功能障碍的内皮细胞的存在起着关键作用。髓系祖细胞能够替代老化或受损的成熟内皮细胞，并能够分化为健康和功能良好的内皮细胞，其发现为将动脉粥样硬化发病机制的传统理论与这些前体细胞在损伤血管壁的修复和缺血组织的新生血管形成中的作用这一不断演变的概念相结合提供了前景。本文综述了动脉粥样硬化生物学方面的最新知识，着重于内皮损伤和修复之间的平衡，以及内皮细胞的更新和替换是维持血管完整性的主要决定因素。
The traditional view of atherosclerosis as a pathological lipid deposition within the artery wall has been redefined by a more complex theory in which the presence of a dysfunctional endothelium plays a pivotal role. The discovery of progenitor cells of myeloid origin, which are able to replace old or injured mature endothelial cells and are able to differentiate into healthy and functional endothelial cells, has offered the prospect of merging the traditional theories on the pathogenesis of atherosclerosis with the evolving concept of a role of these progenitor cells in the repair of the injured vessel wall and the neovascularization of ischemic tissues. This article Summarizes Current knowledge about the biology of atherosclerosis with emphasis on the balance between endothelial injury and repair and on the concept that the turnover and replacement of endothelial cells is a major determinant in the maintenance of vascular integrity.