Physical activity and risk of endometrial cancer in a prospective cohort study (United States)
Physical activity and risk of endometrial cancer in a prospective cohort study (United States)
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DOI：
10.1023/a:1024866827775
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发表时间：
2003-08-01
影响因子：
2.3
通讯作者：
Albanes, D
中科院分区：
文献类型：
--
作者：
Colbert, LH;Lacey, JV;Albanes, D
目的：对美国乳腺癌检测示范项目（BCDDP）随访研究的女性进行前瞻性研究，探讨运动与子宫内膜癌的关系。方法：我们评估了23,369名妇女过去一年的所有类型的身体活动，这些妇女在1987-1989年期间返回了基线问卷，并且没有子宫切除术和/或子宫内膜癌。Cox比例风险模型用于估计在平均8.2年随访期间（截至1995年至1998年）确定的253例确诊子宫内膜癌病例的年龄、受教育程度、奇偶调整率比（RR）和95%置信区间（CI）。结果：与总运动量或剧烈运动量均无剂量-反应关系；然而，与总活动量最低的四分位数相比，活动量较高的四分位数的风险没有显著降低（RR = 0.8, CI = 0.6-1.0）。与中度活动的关联随随访时间的不同而不同：在2年随访间隔（小于或等于2年、2.1-4.9年、5.0-8.0年、bbb8年）中，每日中度活动增加1小时的rr （CI）分别为1.1（1.0,1.2）、1.0（0.9,1.1）、1.0（0.9,1.1）、1.0（0.9,1.1）、1.0（0.9,1.1）和0.8（0.7,1.0）。结论：这些数据表明近期的身体活动与子宫内膜癌的风险没有很强的相关性，长时间的接触和更长时间的随访可能是必要的。
Objective: To examine the physical activity and endometrial cancer relationship in a prospective study of US women enrolled in the Breast Cancer Detection Demonstration Project (BCDDP) Follow-up Study.Methods: We assessed past-year physical activity of all types in 23,369 women who returned the baseline questionnaire (1987-1989) and had no prior hysterectomy and/or endometrial cancer. Cox proportional hazards models were used to estimate age, education, and parity-adjusted rate ratios (RR) and 95% confidence intervals (CI) for the 253 confirmed endometrial cancer cases identified during an average 8.2 years of follow-up (ending 1995 1998).Results: There were no dose-response relationships with either total or vigorous physical activity; however, compared to the lowest total activity quartile, the higher four quartiles had a non-significantly lower risk (RR = 0.8, CI = 0.6-1.0). The association with moderate activity varied with follow-up time: RRs (CI) for a 1 h increase in daily moderate activity within 2-year intervals of follow-up (less than or equal to2, 2.1-4.9, 5.0-8.0, > 8 years) were 1.1 (1.0, 1.2), 1.0 (0.9, 1.1), 1.0 (0.9, 1.1), 1.0 (0.9, 1.1), and 0.8 (0.7, 1.0), respectively.Conclusion: These data suggest that recent physical activity is not strongly related to the risk of endometrial cancer, and that prolonged exposure and longer follow-up may be necessary.