Effect of age on the circadian pattern of sleep and wakefulness in the mouse.
Effect of age on the circadian pattern of sleep and wakefulness in the mouse.
复制标题
年龄对小鼠睡眠和觉醒昼夜节律模式的影响。
DOI：
10.1093/geronj/41.5.579
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Dement,WC
中科院分区：
文献类型：
--
作者：
Welsh,DK;Richardson,GS;Dement,WC
在老年人中，白天小睡很常见，夜间睡眠不稳定，睡眠期通常比年轻人更早开始和结束。由于先前的工作表明啮齿动物可能为这些变化提供有用的动物模型，因此我们对11只年轻成年小鼠和9只老年小鼠的睡眠模式进行了详细的调查。通过手术植入小鼠以进行慢性EEG记录，并在多个昼夜节律周期内监测睡眠状态。在活跃期，与年轻小鼠相比，老年小鼠睡眠时间更长，觉醒时间更短。在休息阶段，年老的老鼠比年轻的老鼠醒着的时间更长，而且睡眠时间更短。然而，没有证据表明老年小鼠的睡眠时间更早。这些结果表明，小鼠可能为进一步研究睡眠和觉醒时间分布的某些年龄相关变化提供了合适的动物模型
In elderly humans, daytime naps are common, nocturnal sleep is poorly consolidated, and the sleep period often begins and ends earlier than in young adults. Because previous work has suggested that rodents may provide a useful animal model for these changes, we conducted a detailed investigation of sleep patterns in 11 young adult and 9 old mice. Mice were surgically implanted for chronic EEG recording, and sleep state was monitored over multiple circadian cycles. During the active phase, old mice spent more time asleep and had shorter wake episodes compared with young mice. During the rest phase, old mice spent more time awake than young mice, and tended to have shorter episodes of sleep. No evidence was found, however, for earlier timing of sleep in older mice. These results suggest that the mouse may provide a suitable animal model for further study of certain age-related changes in temporal distribution of sleep and wakefulness