Unilateral nasal obstruction affects development of cortical orofacial motor representation in the cortical masticatory area of growing rats
Unilateral nasal obstruction affects development of cortical orofacial motor representation in the cortical masticatory area of growing rats
复制标题
单侧鼻塞影响生长大鼠皮质咀嚼区皮质口面运动表征的发育
DOI：
10.1016/j.neulet.2022.136700
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发表时间：
2022
影响因子：
2.5
通讯作者：
Ono Takashi
中科院分区：
文献类型：
--
作者：
Fujita Akiyo;Kato Chiho;Abe Yasunori;Ishidori Hideyuki;Li Ruixin;Thura Aung Phyo;Ogawa Takuya;Okihara Hidemasa;Kokai Satoshi;Ono Takashi
咀嚼皮质区（CMA）调节咀嚼运动。然而，关于呼吸紊乱对CMA功能发育的影响的信息有限。本研究旨在探讨慢性单侧鼻塞（UNO）对生长期CMA的影响。将48只8日龄雄性Wistar白化病大鼠随机分为对照组（CONT，n = 24）和UNO组（n = 24）。在5、7和9周龄时记录动脉血氧饱和度（SpO2）和前二腹肌（AD）中皮质内微刺激（ICMS）阳性部位的数量。在麻醉下进行ICMS。CONT组在每个年龄段的SpO2值均显著高于UNO组。此外，在AD肌肉中阳性ICMS位点的数量在UNO组中显著高于CONT组。右AD比左AD更强烈地受到UNO的影响。此外，还发现P区比A区更强烈地受到UNO的影响。这些结果表明，UNO在发育过程中诱导的CMA，这可能会影响大鼠的呼吸和口面功能的运动代表的变化。因此，我们建议呼吸功能障碍的发展需要及时监测和纠正，以避免生理功能的并发症。
The cortical masticatory area (CMA) regulates masticatory movements. However, there is limited information regarding the effect of respiratory disturbances on the functional development of the CMA. This study aimed to examine the effect of chronic unilateral nasal obstruction (UNO) on the CMA during the growth period. Forty-eight 8-day-old male Wistar albino rats were randomized into control (CONT, n = 24) and UNO (n = 24) groups. Arterial oxygen saturation (SpO2) and the number of positive intracortical microstimulation (ICMS) sites in the anterior digastric (AD) muscle were recorded at 5, 7, and 9 weeks of age. ICMS was performed under anesthesia. The CONT group exhibited significantly higher SpO2values than the UNO group at each age. Furthermore, the number of positive ICMS sites in the AD muscle was significantly higher in the UNO group than in the CONT group at each age. The right AD was more strongly affected by UNO than the left AD. In addition, it was found that the P-area was more strongly affected by UNO than the A-area. These findings suggest that UNO during development induces changes in the motor representation in the CMA, which may affect respiratory and orofacial functions in rats. Therefore, we suggest that the development of respiratory dysfunction needs to be monitored and corrected promptly to avoid complications in physiological function.