EFFECTS OF INDOMETHACIN ON BRAIN BLOOD-FLOW, CEREBRAL METABOLISM, AND SAGITTAL SINUS PROSTANOIDS AFTER HYPOXIA
EFFECTS OF INDOMETHACIN ON BRAIN BLOOD-FLOW, CEREBRAL METABOLISM, AND SAGITTAL SINUS PROSTANOIDS AFTER HYPOXIA
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DOI：
10.1152/ajpheart.1995.269.4.h1450
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发表时间：
1995-10-01
影响因子：
4.8
通讯作者：
STONESTREET, BS
中科院分区：
文献类型：
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作者：
COYLE, MG;OH, W;STONESTREET, BS
我们测试的假设，从缺氧恢复过程中，新生仔猪表现出posthypopoenia脑充血，吲哚美辛预处理的仔猪表现出posthypopoenia脑灌注不足，吲哚美辛引起的变化是剂量依赖性的，并与前列腺素的损失。我们研究了暴露于缺氧40分钟后，与高（5毫克/公斤，n = 9）或低（0.3毫克/公斤，n = 8）剂量的吲哚美辛或安慰剂（n = 9）预处理的小猪，并允许恢复120分钟。在安慰剂和低剂量的预处理组，总的和局部脑血流量增加缺氧期间，但回到基线缺氧后10分钟。高剂量吲哚美辛预处理与缺氧后10分钟恢复到与吲哚美辛治疗后缺氧发作前相似的值时某些脑区的缺氧后低灌注相关。在缺氧期间和缺氧后，安慰剂组和低剂量组的脑氧代谢率保持不变，而高剂量组在缺氧期间显著降低。在整个研究中，两个吲哚美辛治疗组的鼻窦前列环素均显著降低。我们得出结论，在新生仔猪中未观察到产后充血。这一发现并没有改变预处理与治疗剂量的吲哚美辛，而药理剂量与选择性低灌注到某些脑区缺氧前和缺氧恢复过程中。
We tested the hypotheses that during recovery from hypoxia, newborn piglets exhibit a posthypoxic cerebral hyperemia, indomethacin-pretreated piglets exhibit a posthypoxic cerebral hypoperfusion, and that the changes caused by indomethacin are dose dependent and related to the loss of prostanoids. We studied piglets exposed to 40 min of hypoxia after pretreatment with high (5 mg/kg, n = 9) or low (0.3 mg/kg, n = 8) doses of indomethacin or placebo (n = 9) and allowed to recover for 120 min. In the placebo and low-dose pretreatment groups, total and regional brain blood flow increased during hypoxia but returned to baseline 10 min after hypoxia. High-dose indomethacin pretreatment was associated with a posthypoxic hypoperfusion to certain brain regions at 10 min of recovery to values similar to those after indomethacin treatment before the onset of hypoxia. During and after hypoxia, the cerebral metabolic rate of oxygen was preserved in both the placebo and low-dose groups and decreased significantly during hypoxia in the high-dose group. Sagittal sinus prostacyclin was reduced significantly in both indomethacin-treated groups throughout the study. We conclude that a posthypoxic hyperemia is not observed in newborn piglets. This finding was not altered by pretreatment with a therapeutic dose of indomethacin, whereas a pharmacological dose was associated with selective hypoperfusion to certain brain regions both before hypoxia and during recovery from hypoxia.