Lipid peroxidation in cell death.
Lipid peroxidation in cell death.
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DOI：
10.1016/j.bbrc.2016.10.086
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发表时间：
2017-01-15
影响因子：
3.1
通讯作者：
Stockwell BR
中科院分区：
文献类型：
--
作者：
Gaschler MM;Stockwell BR
氧化还原稳态的破坏是许多病理状况的关键表型。尽管多种氧化化合物（例如过氧化氢）被广泛认为是氧化应激的介质和诱导剂，但人们越来越多地关注脂质氢过氧化物作为死亡和疾病的关键介质的作用。脂质作为细胞膜的主要成分，对于维持细胞结构的完整性具有不可或缺的作用。脂质的过度氧化会改变细胞膜的物理特性，并可能导致蛋白质和核酸的共价修饰。本综述讨论了生物系统中脂质过氧化物的合成、毒性、降解和检测。此外，还强调了脂质过氧化在疾病和死亡中的作用，并讨论了控制脂质过氧化物积累的策略。
Disruption of redox homeostasis is a key phenotype of many pathological conditions. Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized as mediators and inducers of oxidative stress, increasingly, attention is focused on the role of lipid hydroperoxides as critical mediators of death and disease. As the main component of cellular membranes, lipids have an indispensible role in maintaining the structural integrity of cells. Excessive oxidation of lipids alters the physical properties of cellular membranes and can cause covalent modification of proteins and nucleic acids. This review discusses the synthesis, toxicity, degradation, and detection of lipid peroxides in biological systems. Additionally, the role of lipid peroxidation is highlighted in disease and death, and strategies to control the accumulation of lipid peroxides are discussed.