DISUSE ATROPHY OF PERIODONTIUM IN MICE FOLLOWING PARTIAL LOSS OF FUNCTION
DISUSE ATROPHY OF PERIODONTIUM IN MICE FOLLOWING PARTIAL LOSS OF FUNCTION
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DOI：
10.1016/0003-9969(66)90120-8
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发表时间：
1966-01-01
影响因子：
3
通讯作者：
COHN, SA
中科院分区：
文献类型：
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作者：
COHN, SA
在两个相关实验中，在25日龄时拔除小鼠的右侧第一上颌磨牙或右侧第二和第三上颌磨牙，以观察部分功能丧失对右侧第一和第二下颌牙齿的牙间牙周组织的长期影响。此后每 50 天处死每个实验组的四只动物和三只完整的对照动物。 900 天的显微镜观察显示，部分功能丧失导致齿间区域出现中度但进行性的牙周萎缩；当拔除第二和第三上颌磨牙时，这种萎缩更加明显。牙间骨大量损失，牙骨质-牙釉质交界处的牙骨质有一定的吸收，伴随而来的是牙周膜纤维的脱离，上皮附着的根尖增殖以及牙间隙的狭窄。研究表明，如果选择性地去除小鼠的某一特定下颌磨牙的功能，则可以使该磨牙超萌出。尽管失去了相对的牙齿，下颌磨牙似乎仍在不断尝试保持彼此的功能关系，牙骨质的连续沉积和新的横隔纤维组的形成证明了这一点。这些发现表明，部分功能可以发挥极其重要的作用，不仅可以减少废用性萎缩对牙周组织的影响，而且可以维持牙齿彼此的功能附着。
In two related experiments either right first maxillary molars or right second and third maxillary molars of mice were extracted at 25 days of age to observe the long-term effect of partial loss of function on the interdental periodontium of the right first and second mandibular teeth. Four animals from each experimental group and three intact controls were sacrificed every 50 days thereafter. Microscopic observations over a 900-day period revealed that partial loss of function caused a moderate but progressive periodontal atrophy in the interdental region; this atrophy was more pronounced when the second and third maxillary molars were extracted. There was considerable loss of interdental bone, some resorption of cementum at the cemento-enamel junction, a concomitant detachment of fibers of the periodontal ligament, an apical proliferation of the epithelial attachment and a narrowing of the interdental space. The study showed that a particular mandibular molar in the mouse can be made to supraerupt if function is selectively removed from it. There appeared to be a constant attempt by the mandibular molars, in spite of the loss of opposing teeth, to retain functional relationships with each other, as evidenced by the continuous deposition of cementum and the formation of new groups of transseptal fibers. These findings suggest that partial function can play an extremely important role, not only in reducing the effects of disuse atrophy on the periodontium, but also in maintaining functional attachments of the teeth to each other.