CHRONIC MENINGOCOCCEMIA; EPIDEMIOLOGY, DIAGNOSIS AND TREATMENT.
CHRONIC MENINGOCOCCEMIA; EPIDEMIOLOGY, DIAGNOSIS AND TREATMENT.
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慢性脑膜炎球菌血症；
DOI：
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发表时间：
1965
期刊：
影响因子：
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通讯作者：
D. Bloom
中科院分区：
文献类型：
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作者：
D. Bloom
本文报告4例慢性脑膜炎双球菌血症，其特征性表现为反复发作的发热、寒战、盗汗、头痛、厌食，并伴有皮疹和关节痛。所有病例的诊断均通过血培养确定。磺胺类药物治疗三例，青霉素治疗四例，均迅速痊愈。然而，最近发现的一种磺胺耐药脑膜炎球菌菌株表明，应对所有脑膜炎球菌病病例进行药物敏感性试验。在等待这些测试结果的报告时，临床医生应该开始用大剂量的磺胺和青霉素联合治疗。
This report describes four cases of chronic meningococcemia with the characteristic manifestations of recurrent episodes of fever, chills, night sweats, headache and anorexia, associated with skin rash and arthralgias. The diagnosis was established in all instances by blood culture. Administration of sulfonamides in three cases and penicillin in the fourth resulted in prompt recovery. The recent finding of a strain of sulfonamide-resistant meningococci, however, indicates that antibiotic-sensitivity tests should be carried out in all cases of meningococcal disease. While waiting for the results of such tests to be reported, the clinician should initiate treatment with large doses of a sulfonamide and penicillin in combination.