MULTIPLE PRIMARY MELANOMAS - AN ANALYSIS OF CANCER REGISTRY DATA FROM VICTORIA AND NEW-SOUTH-WALES
MULTIPLE PRIMARY MELANOMAS - AN ANALYSIS OF CANCER REGISTRY DATA FROM VICTORIA AND NEW-SOUTH-WALES
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DOI：
10.1097/00008390-199512000-00007
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发表时间：
1995-12-01
影响因子：
2.2
通讯作者：
COATES, M
中科院分区：
文献类型：
--
作者：
GILES, G;STAPLES, M;COATES, M
所有原发性浸润性皮肤恶性黑色素瘤（CMM）诊断在维多利亚和新南威尔士州从1985年至1989年获得的人口为基础的癌症登记。共有14，590名首次CMMs患者接受了至少2年的随访，在此期间确定了496名多原发CMMs。在研究人群中，3.4%的人发展了第二个主要CMM，0.3%的人发展了三个或更多。据估计，4.5%的人会在第一次CMM后的5年内发生第二次CMM，男性的风险更高，特别是70岁以上的男性。关于异时性原发灶，只有年龄和第一原发灶的厚度是第二原发灶厚度的重要预测因素：老年人的CMM往往更厚，第二原发灶通常比第一原发灶更薄。身体部位一致性高于预期的机会，特别是同步诊断。异时性原发灶的高度部位一致性支持了第一个CMM附近的皮肤可能经历了“场效应”的假设，使其对恶性肿瘤的易感性增加。
All primary invasive cutaneous malignant melanomas (CMM) diagnosed in Victoria and New South Wales from 1985 to 1989 were obtained from the population-based cancer registries. Altogether 14,590 people with first CMMs were followed for at least 2 years, during which time 496 multiple primary CMMs were identified. Of the study population, 3.4% developed a second primary CMM and 0.3% developed three or more. It was estimated that 4.5% of people would develop a second CMM within 5 years of the first and that the risk was higher in males, particularly in men aged over 70 years. With regard to metachronous primaries, only age and thickness of the first primary were significant predictors of the thickness of the second: older people tended to have thicker CMMs and second CMMs were generally thinner than the first. Body site concordance was higher than expected by chance, particularly for synchronous diagnoses. The high degree of site concordance of metachronous primaries lent support to the hypothesis that skin adjacent to the first CMM might have undergone a 'field effect', rendering it at increased susceptibility to malignancy.