Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy.
Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy.
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DOI：
10.1016/j.intimp.2014.06.040
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发表时间：
2014-10
影响因子：
5.6
通讯作者：
Jadus MR
中科院分区：
文献类型：
--
作者：
Ge L;Hoa NT;Wilson Z;Arismendi-Morillo G;Kong XT;Tajhya RB;Beeton C;Jadus MR
大钾离子通道通常被称为各种各样的名称（max - k, KCNMA1, slo，拉伸活化钾通道，KCa1.1）。每个名称反映了这个离子通道显示的不同物理性质。这种跨膜通道几乎存在于身体的每一种细胞类型上，并且对这种组织类型有其独特的作用。BKα通道包含从细胞内储存中释放钾离子的孔。这种离子通道存在于细胞膜、内质网、高尔基体和线粒体上。复杂的剪接途径产生不同的同工异构体。BKα通道可以磷酸化、棕榈酰化和肉芽化。BK由同型四聚体组成，与β链和γ链相互作用。这些辅助蛋白对BKα通道的功能提供了进一步的调节作用。BK通道在细胞分裂和迁移中起着重要的作用。在这篇综述中，我们将重点介绍BK通道的生物学，特别是它在癌症免疫反应中的作用。最近的蛋白质组学研究已经将BK通道与多种蛋白质联系起来。其中一些相互作用进一步揭示了BK通道在癌症，特别是脑肿瘤中的作用。这一综述表明，BK通道与癌细胞的细胞内组分具有复杂的相互作用，并且仍有许多秘密有待发现。
The Big Potassium (BK) ion channel is commonly known by a variety of names (Maxi-K, KCNMA1, slo, Stretch-activated potassium channels, KCa1.1). Each name reflects a different physical property displayed by this single ion channel. This transmembrane channel is found on nearly every cell type of the body and has its own distinctive roles for that tissue type. The BKα channel contains the pore that releases potassium ions from intracellular stores. This ion channel is found on the cell membrane, endoplasmic reticulum, Golgi and mitochondria. Complex splicing pathways produce different isoforms. The BKα channels can be phosphorylated, palmitoylated and myristylated. BK is composed of a homo-tetramer that interacts with β and γ chains. These accessory proteins provide a further modulating effect on the functions of BKα channels. BK channels play important roles in cell division and migration. In this review, we will focus on the biology of BK channels, especially its role, and that it has in the immune response towards cancer. Recent proteomic studies have linked BK channels with various proteins. Some of these interactions offer further insight into the role that BK channels have with cancers, especially with brain tumors. This review shows that BK channels have a complex interplay with intracellular components of cancer cells and still have plenty of secrets to be discovered.