CLINICAL AND LABORATORY EVALUATION OF CYTOMEGALOVIRUS-INDUCED MONONUCLEOSIS IN PREVIOUSLY HEALTHY-INDIVIDUALS - REPORT OF 82 CASES
CLINICAL AND LABORATORY EVALUATION OF CYTOMEGALOVIRUS-INDUCED MONONUCLEOSIS IN PREVIOUSLY HEALTHY-INDIVIDUALS - REPORT OF 82 CASES
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DOI：
10.1097/00005792-198603000-00005
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发表时间：
1986-03-01
期刊：
影响因子：
1.6
通讯作者：
MULLER, N
中科院分区：
文献类型：
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作者：
HORWITZ, CA;HENLE, W;MULLER, N
1965年，Klemola和Kaariainen描述了一种由巨细胞病毒（CMV）引起的发热性疾病，患者未接受免疫抑制治疗或输血，近期未接受心脏手术（15-18）。本病伴有发热、脾肿大、肝功能异常、嗜异性抗体试验阴性、血涂片与eb病毒（EBV）诱导的传染性单核细胞增多症（IM）难以区分。这些患者中的大多数没有扁桃体咽炎和后颈淋巴结病，并且与EBV-IM患者一样，被认为具有自限性疾病。最近，Jordan等人描述了在10个月内遇到的9例类似病例，并得出结论，cmv单核细胞增多症是年轻人中的常见疾病，应在所有嗜中性粒细胞阴性患者中考虑，包括淋巴结病和脾肥大症患者（14）。在过去的15年里，我们注意到cmv单核细胞增多症患者通常会出现初始诊断问题。他们经常因各种各样的临床诊断而住院，包括病因不明的发热、盆腔炎、急性白血病、活动性病毒性肝炎、系统性红斑狼疮和Guil- 1
In 1965, Klemola and Kaariainen described a febrile illness due to cytomegalovirus (CMV) in patients who had not received immunosuppressive therapy or blood transfusions and had not under-gone recent heart surgery (15–18). This illness was associated with fever, splenomegaly, abnormal liver function, negative heterophil antibody tests, and blood smears that were indistinguishable from those of Epstein-Barr-virus-(EBV)-induced infec-tious mononucleosis (IM). The majority of these patients lacked tonsillar pharyngitis and posterior cervical lymphadenopathy and, like patients with EBV–IM, were thought to have self-limited illnesses. More recently, Jordan et al described nine similar cases encountered over a 10-month period and concluded that CMV-mononucleosis was a common disease among young adults and should be considered in all heterophil-negative patients, including those with lymphadenopathy and spleno-megaly (14).Over the past 15 years, we have noted that pa-tients with CMV-mononucleosis often present initial diagnostic problems. They are often hospital-ized with a wide variety of clinical diagnoses, including fever of undetermined etiology, pelvic inflammatory disease, acute leukemia, active viral hepatitis, systemic lupus erythematosus, and Guil-