REDUCTION TO NORMAL OF PLASMA GLUCOSE IN JUVENILE DIABETES BY SUBCUTANEOUS ADMINISTRATION OF INSULIN WITH A PORTABLE INFUSION PUMP
REDUCTION TO NORMAL OF PLASMA GLUCOSE IN JUVENILE DIABETES BY SUBCUTANEOUS ADMINISTRATION OF INSULIN WITH A PORTABLE INFUSION PUMP
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DOI：
10.1056/nejm197903153001101
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发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
FELIG, P
中科院分区：
文献类型：
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作者：
TAMBORLANE, WV;SHERWIN, RS;FELIG, P
为改善血糖控制，皮下注射胰岛素。在7名12-17岁的青少年糖尿病患者中，在餐前使用便携式输液泵，以基础速率和脉冲剂量递增。2-4天后，平均血糖(.+-.(1 S.E.)94年。+-。5 mg/dl明显低于按常规方法给药时的正常剂量(243.+-)。28 P<；0.01)或相当于泵给药的总剂量(150。+-)。15，P<；0.01)。血糖的最大波动也低于常规治疗观察到的50-150 mg/dl(P<；0.001)。7例患者中有6例在泵治疗过程中糖尿消失。所有受试者都没有低血糖。对于患有脆性青少年糖尿病的门诊患者，可以使用便携式S.C.将血糖降至正常。胰岛素输注系统2-4天。该技术长期应用的可行性和价值有待探索。
To improve plasma glucose control, insulin was administered s.c. in 7 ambulatory patients with juvenile diabetes (12-17 yr of age), using a portable infusion pump at a basal rate with pulse-dose increments before meals. After 2-4 days, the mean plasma glucose (.+-. 1 S.E.) of 94 .+-. 5 mg/dl was markedly lower than when insulin was given by conventional methods in the patients'' usual dose (243 .+-. 28 P < 0.01) or in a total dose equivalent to that administered with the pump (150 .+-. 15, P < 0.01). Maximal fluctuations in plasma glucose were also 50-150 mg/dl below those observed with conventional treatment (P < 0.001). Glycosuria was eliminated in 6 of 7 patients during pump treatment. None of the subjects had hypoglycemia. Plasma glucose can be lowered to normal in ambulatory patients with brittle juvenile diabetes using a portable, s.c. insulin infusion system for 2-4 days. The feasibility and value of the long-term application of this technique need exploration.