A proline-catalyzed asymmetric Robinson annulation reaction
A proline-catalyzed asymmetric Robinson annulation reaction
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DOI：
10.1016/s0040-4039(00)01180-1
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发表时间：
2000-09-02
影响因子：
1.8
通讯作者：
Barbas, CF
中科院分区：
文献类型：
--
作者：
Bui, T;Barbas, CF
本文报道了Wieland-Miescher酮（5）的一步不对称选择性合成。我们表明，L-脯氨酸以及一些其他的手性胺可以作为催化剂的两个步骤的罗宾逊成环反应。其他手性胺被鉴定为Michael和Aldol加成反应的催化剂。(C)2000爱思唯尔科技有限公司版权所有。
A single-step enantioselective synthesis of the Wieland-Miescher ketone (5) is presented. We show that L-proline as well as a number of other chiral amines can act as catalysts of both steps of the Robinson annulation reaction. Other chiral amines are identified as catalysts of Michael and aldol addition reactions. (C) 2000 Elsevier Science Ltd. All rights reserved.