Bisphenol A, 4-t-octylphenol, and 4-nonylphenol determination in serum by Hybrid Solid Phase Extraction-Precipitation Technology technique tailored to liquid chromatography-tandem mass spectrometry
Bisphenol A, 4-t-octylphenol, and 4-nonylphenol determination in serum by Hybrid Solid Phase Extraction-Precipitation Technology technique tailored to liquid chromatography-tandem mass spectrometry
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DOI：
10.1016/j.jchromb.2015.02.009
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发表时间：
2015-04-01
影响因子：
3
通讯作者：
Thomaidis, Nikolaos S.
中科院分区：
文献类型：
--
作者：
Asimakopoulos, Alexandros G.;Thomaidis, Nikolaos S.
建立了同时测定人血清中双酚A、4-叔辛基酚和4-壬基酚的液相色谱-串联质谱（LC-MS/MS）分析方法。第一次，电喷雾离子化（ESI）参数的探针位置，电压电位，鞘气流量，辅助气体流量，和离子转移管温度进行了深入研究和优化，为每一种苯酚的单变量方法。因此，报告了较低的仪器检测限，证明在0.2 ng/mL（溶剂基质中）下具有优异的进样重复性（RSD
A rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and optimized for the simultaneous determination of bisphenol A, 4-t-octylphenol and 4-nonylphenol in human blood serum. For the first time, the electrospray ionization (ESI) parameters of probe position, voltage potential, sheath gas flow rate, auxiliary gas flow rate, and ion transfer tube temperature were thoroughly studied and optimized for each phenol by a univariate approach. As a consequence, low instrumental limits of detection were reported, demonstrating at 0.2 ng/mL (in solvent matrix) excellent injection repeatability (RSD