Hepatic immunopathology during occult hepacivirus re-infection.
Hepatic immunopathology during occult hepacivirus re-infection.
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DOI：
10.1016/j.virol.2017.08.037
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发表时间：
2017-12
期刊：
影响因子：
3.7
通讯作者：
Reeves RK
中科院分区：
文献类型：
--
作者：
Manickam C;Martinot AJ;Jones RA;Varner V;Reeves RK
Despite drug advances for Hepatitis C virus (HCV), re-infections remain prevalent in high-risk populations. Unfortunately, the role of preexisting viral immunity and how it modulates re-infection is unclear. GBV-B infection of common marmosets is a useful model to study tissue immune responses in hepacivirus infections, and in this study we re-challenged 4 animals after clearance of primary viremia. Although only low-to-absent viremia was observed following re-challenge, GBV-B viral RNA was detectable in liver, confirming re-infection. Microscopic hepatic lesions indicated severe-to-mild lymphocyte infiltration and fibrosis in 3 out of 4 animals. Further, GBV-B-specific T cells were elevated in animals with moderate-to-severe hepatopathology, and up to 3-fold increases in myeloid dendritic and activated natural killer cells were observed after infection. Our data indicate that occult hepacivirus re-infections occur and that new liver pathology is possible even in the presence of anti-hepacivirus T cells and in the absence of high viremia.
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