Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion
Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion
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DOI：
10.1126/sciadv.abb1093
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发表时间：
2020-08-01
期刊：
影响因子：
13.6
通讯作者：
Rogers, John A.
中科院分区：
文献类型：
--
作者：
Koo, Jahyun;Kim, Sung Bong;Rogers, John A.
提供无线可编程药代动力学控制的植入式药物释放平台在激素失衡、恶性癌症、糖尿病等疾病的高级治疗方案中具有潜力。我们提出了一个具有这种功能的系统，其中成分材料经过完全的生物吸收，以在完成释放过程的最后阶段后消除患者的装置负荷。在这里，生物可吸收的聚酸酐储层将药物储存在指定的储层中而不会泄漏，直到无线触发阀门结构打开以允许释放。这些阀门通过一种电化学机制来运行，这种机制是由无线的、生物可吸收的能量收集单元通过的电流引起的几何加速腐蚀。细胞培养的评估证明了该技术通过释放药物阿霉素治疗癌组织的有效性。在活体动物模型中，对具有多个独立控制释放事件的平台的完整体内研究表明，通过定时给药胰岛素可以控制血糖水平。
Implantable drug release platforms that offer wirelessly programmable control over pharmacokinetics have potential in advanced treatment protocols for hormone imbalances, malignant cancers, diabetic conditions, and others. We present a system with this type of functionality in which the constituent materials undergo complete bioresorption to eliminate device load from the patient after completing the final stage of the release process. Here, bioresorbable polyanhydride reservoirs store drugs in defined reservoirs without leakage until wirelessly triggered valve structures open to allow release. These valves operate through an electrochemical mechanism of geometrically accelerated corrosion induced by passage of electrical current from a wireless, bioresorbable power-harvesting unit. Evaluations in cell cultures demonstrate the efficacy of this technology for the treatment of cancerous tissues by release of the drug doxorubicin. Complete in vivo studies of platforms with multiple, independently controlled release events in live-animal models illustrate capabilities for control of blood glucose levels by timed delivery of insulin.