CIGARETTE-SMOKING AND DRINKING OF ALCOHOL ARE NOT ASSOCIATED WITH RAPID PROGRESSION TO ACQUIRED-IMMUNODEFICIENCY-SYNDROME AMONG HOMOSEXUAL MEN IN NORWAY
CIGARETTE-SMOKING AND DRINKING OF ALCOHOL ARE NOT ASSOCIATED WITH RAPID PROGRESSION TO ACQUIRED-IMMUNODEFICIENCY-SYNDROME AMONG HOMOSEXUAL MEN IN NORWAY
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DOI：
10.1177/140349489402200309
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发表时间：
1994-09-01
期刊：
影响因子：
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通讯作者：
PETERSEN, G
中科院分区：
文献类型：
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作者：
ESKILD, A;PETERSEN, G
为探讨吸烟和饮酒对获得性免疫缺陷综合征（AIDS）进展的影响，对80例HIV感染的男同性恋者进行了前瞻性研究。 2名男性失访。 平均随访时间为62个月，随访期结束时，78名受试者中有26名（33%）被诊断为艾滋病。 在控制年龄、诊断年份、男性终生伴侣数和肛交频率后，每日吸烟1-20支的人群被诊断为艾滋病的校正相对危险度为0.4（0.2-1.2，95%置信区间）和1.1（0.4-2.7，95%置信区间）的组吸烟超过20支烟，而非吸烟组。 与不常饮酒者相比，每日饮酒者进展为艾滋病的校正相对风险为0.8（0.3-2.2，95%置信区间）。 经常或经常接受肛交和超过500个终身男性伴侣的调整后相对危险度分别为2.2和2.0。 然而，这些估计值并不显著高于1.0。在这项研究以及其他研究中发现的吸烟、饮酒与艾滋病进展之间缺乏正相关，这可能对理解艾滋病的发病机制和咨询艾滋病毒感染者有意义。
In order to study the influence of cigarette smoking and drinking of alcohol on the progression to acquired immunodeficiency syndrome (AIDS), eighty HIV infected homosexual men were included in a prospective study from the date of diagnosed HIV seropositivity. Two men were lost to follow-up. The mean follow-up time was 62 months.By the end of the follow-up period 26 out of 78 subjects (33%) were diagnosed with AIDS. When controlling for age, year of HIV diagnosis, number of male lifetime partners and frequency of receptive anal intercourse, the adjusted relative risk of being diagnosed with AIDS for the group smoking 1-20 cigarettes daily was 0.4 (0.2-1.2, 95% confidence interval) and 1.1 (0.4-2.7, 95% confidence interval) for the group smoking more than 20 cigarettes daily, as opposed to the non-smoking group. The adjusted relative risk of progression to AIDS for daily alcohol drinkers as opposed to less frequent drinkers was 0.8 (0.3-2.2, 95% confidence interval). The adjusted relative risks of receptive anal intercourse often or usually and more than 500 lifetime male partners were 2.2 and 2.0, respectively. These estimates, however, were not significantly above 1.0.The lack of positive association between cigarette smoking, drinking of alcohol and progression to AIDS found in this study as well as in other studies, may have implication for the understanding of the pathogenesis of the HIV disease and for counselling HIV infected subjects.