The optomotor response:: A robust first-line visual screening method for mice
The optomotor response:: A robust first-line visual screening method for mice
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DOI：
10.1016/j.visres.2004.12.015
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发表时间：
2005-05-01
期刊：
影响因子：
1.8
通讯作者：
Serge, P
中科院分区：
文献类型：
--
作者：
Abdejalil, J;Hamid, M;Serge, P
在暗视和明视条件下，发现光栅的旋转引起小鼠的头部运动。最高的空间频率引起这个optomotor反应提供了一个估计的视觉敏锐度。在雄性C57 BL/6J小鼠中，视敏度从暗视条件下的0.26 cpd增加到明视条件下的0.52 cpd，而在129/SvPas小鼠中，在两组条件下均为0.52 cpd。在白化病CD 1小鼠和rd1视网膜变性小鼠中未检测到视动反应，尽管CD 1小鼠的光敏感性通过畏光症和正常视网膜电图证实。这种快速而廉价的方法可以为转基因小鼠和经抗抑郁药治疗的小鼠的视觉表现提供强有力的测试。(c)2005爱思唯尔有限公司保留所有权利。
In both scotopic and photopic conditions, the rotation of a grating was Found to elicit head movements in mice. The highest spatial frequency eliciting this optomotor response provided an estimate Of Visual acuity. In male C57BL/6J mice, visual acuity increased from 0.26 cpd in scotopic conditions to 0.52 cpd in photopic conditions whereas it was 0.52 cpd in both sets of conditions in 129/SvPas mice. No optomotor response was detected in albino CD1 mice and rd1 retinal degeneration mice although light sensitivity in CD1 mice was attested by photophobia and normal electroretinograms. This rapid and cheap method could provide a powerful test of visual performance in genetically modified and pharmacologically treated mice. (c) 2005 Elsevier Ltd. All rights reserved.