Symbiospirols: novel long carbon-chain compounds isolated from symbiotic marine dinoflagellate Symbiodinium sp.
Symbiospirols: novel long carbon-chain compounds isolated from symbiotic marine dinoflagellate Symbiodinium sp.
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DOI：
10.1021/ol900299x
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发表时间：
2009-05
期刊：
影响因子：
5.2
通讯作者：
Y. Tsunematsu;O. Ohno;Kaori Konishi;Kaoru Yamada;M. Suganuma;D. Uemura
中科院分区：
文献类型：
--
作者：
Y. Tsunematsu;O. Ohno;Kaori Konishi;Kaoru Yamada;M. Suganuma;D. Uemura
从共生甲藻Symbiodinium sp.中分离得到3个分子量为1207的长碳链化合物Symbiospipirin A、B和C，并通过1D和2D NMR谱和降解反应确定了它们的平面结构和部分相对立体化学。共生螺环素由一个C67-直链组成，具有一个β，β '-二羟基酮部分、八个羟基、一个四氢吡喃环和两个1，6-二氧杂螺[4，4]壬烷环。Symbiospirol A对L-磷脂酰丝氨酸诱导的PKC活化具有抑制作用。
Symbiospirols A, B, and C, long carbon-chain compounds with a molecular weight of 1207 were isolated from the cultured symbiotic dinoflagellate Symbiodinium sp. Their planar structures and partial relative stereochemistries were elucidated based on 1D and 2D NMR spectra and a degradation reaction. Symbiospirols consisted of a C67-linear chain with a beta,beta'-dihydroxyl ketone moiety, eight hydroxyl groups, one tetrahydropyran ring, and two 1,6-dioxaspiro[4,4]nonane rings. Symbiospirol A had an inhibitory effect against l-phosphatidylserine-induced PKC activation.