Histomorphometric evaluation of alveolar bone turnover between the maxilla and the mandible during experimental tooth movement in dogs
Histomorphometric evaluation of alveolar bone turnover between the maxilla and the mandible during experimental tooth movement in dogs
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DOI：
10.1016/j.ajodo.2006.12.013
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发表时间：
2008-06-01
影响因子：
3
通讯作者：
Garetto, Lawrence P.
中科院分区：
文献类型：
--
作者：
Deguchi, Toru;Takano-Yamamoto, Teruko;Garetto, Lawrence P.
介绍：本研究旨在通过对犬正畸牙移动过程中牙槽骨的组织形态计量学特征进行定量分析，探讨正畸牙移动过程中上、下颌牙槽骨数量和质量的变化特点。方法：从微型种植体向前磨牙施加200至250 g的力，持续4周或12周。上颌和下颌牙标本包埋和切片在100 μ m的矢状面进行显微镜检查。结果：上颌正畸牙移动量明显大于下颌。主要的组织形态学分析表明，牙齿移动4周后，骨吸收参数的边际增加与张力和压缩部位的骨体积减少有关。另一方面，牙齿移动12周后，二次组织形态学分析表明骨形成率增加，导致编织骨形成增加，特别是在张力部位。结论：临床上，上颌骨和下颌骨对正畸力的反应不同，导致牙齿移动量的显着差异。正畸牙齿移动过程中不同时间点的颌骨间一级和二级组织形态计量学指标的显著差异可能影响正畸患者牙齿移动的量和速度。此外，正畸牙齿移动的特点是区域加速现象，表现为增加骨转换的牙槽突。
Introduction: The purpose of this study was to quantify the histomorphometric properties of alveolar bone to identify the characteristics of the changes of quantity and quality of alveolar bone between the maxilla and the mandible during orthodontic tooth movement in dogs. Methods: A force of 200 to 250 g was applied from miniature implants to the premolars for either 4 or 12 weeks. Maxillary and mandibular tooth specimens were embedded and sectioned at 100 mu m in the sagittal plane for microscopic examination. Results: Significantly more orthodontic tooth movement was observed for maxillary than for mandibular teeth. The primary histomorphometric analysis indicated that, after 4 weeks of tooth movement, a marginal increase in resorptive parameters was associated with a decrease of bone volume at both the tension and compression sites. On the other hand, after 12 weeks of tooth movement, secondary histomorphometric analysis indicated an increase in the bone formation rate, resulting in increased woven bone formation, especially at the tension sites. Conclusions: Clinically, maxillary and mandibular bone responds differently to orthodontic force, resulting in a significant difference in the amounts of tooth movement. Significant differences in the primary and secondary histomorphometric indexes between the jaws and at the different time points during orthodontic tooth movement might affect the amount and rate of tooth movement in orthodontic patients. Moreover, orthodontic tooth movement is characterized by a regional acceleratory phenomenon, manifested as increased bone turnover in the alveolar process.