Clinical implications of thermal therapy in lifestyle-related diseases
Clinical implications of thermal therapy in lifestyle-related diseases
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DOI：
10.1177/153537020322801023
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发表时间：
2003-11-01
影响因子：
3.2
通讯作者：
Tei, C
中科院分区：
文献类型：
--
作者：
Biro, S;Masuda, A;Tei, C
全身热疗，如温水浴和桑拿浴，诱导全身血管舒张。结果发现，反复桑拿治疗（60 ℃，15分钟）改善充血性心力衰竭患者的血流动力学参数，临床症状，心功能和血管内皮功能。血管内皮功能在患有生活方式相关疾病的受试者中受损，所述生活方式相关疾病例如高血压、高脂血症、糖尿病、肥胖和吸烟。桑拿疗法也改善了这些受试者的内皮功能障碍，提示了对动脉粥样硬化的预防作用。在动物实验中，桑拿疗法增加了血管内皮型一氧化氮合酶（eNOS）的mRNA和蛋白水平。在食欲不振的正常体重患者中，反复桑拿治疗增加了血浆ghrelin浓度和每日热量摄入，并改善了进食行为。在肥胖患者中，桑拿治疗2周后体重和体脂显著降低，而血浆ghrelin浓度未增加。根据这些数据，桑拿疗法可能是一种有前途的治疗与生活方式有关的疾病的患者。
Systemic thermal therapy, such as taking a warm-water bath and sauna, induces systemic vasodilation. It was found that repeated sauna therapy (60degreesC for 15 min) improved hemodynamic parameters, clinical symptoms, cardiac function, and vascular endothelial function in patients with congestive heart failure. Vascular endothelial function is impaired in subjects with lifestyle-related diseases, such as hypertension, hyperlipidemia, diabetes mellitus, obesity, and smoking. Sauna therapy also improved endothelial dysfunction in these subjects, suggesting a preventive role for atherosclerosis. In animal experiments, sauna therapy increases mRNA and protein levels of endothelial nitric oxide synthase (eNOS) in aortas. In normal-weight patients with appetite loss, repeated sauna therapy increased plasma ghrelin concentrations and daily caloric intake and improved feeding behavior. In obese patients, the body weight and body fat significantly decreased after 2 weeks of sauna therapy without increase of plasma ghrelin concentrations. On the basis of these data, sauna therapy may be a promising therapy for patients with lifestyle-related diseases.